441788-45-0

Basic information

• Product Name: (R_S,S)-N-(3-hydroxy-1,3-diphenylpropylidene)-tert-butanesulfinamide
• Synonyms: (R_S,S)-N-(3-hydroxy-1,3-diphenylpropylidene)-tert-butanesulfinamide
• CAS NO: 441788-45-0
• Molecular Weight: 329.463
• Mol File: 441788-45-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R_S,S)-N-(3-hydroxy-1,3-diphenylpropylidene)-tert-butanesulfinamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R_S,S)-N-(3-hydroxy-1,3-diphenylpropylidene)-tert-butanesulfinamide(441788-45-0)
• EPA Substance Registry System: (R_S,S)-N-(3-hydroxy-1,3-diphenylpropylidene)-tert-butanesulfinamide(441788-45-0)

Safety Data

• Hazardous Substances Data: 441788-45-0(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 729559-17-5 (E)-(±)-N-α-methyl(phenylmethylidene)-tert-butanesulfinamide 
• 220263-59-2 (R_S)-2-methyl-N-(1-phenylethylidene)propane-2-sulfinamide 

Downstream Products

• 441788-55-2 (R_S,1S,3S)-2-methylpropane-2-sulfinic acid (3-hydroxy-1,3-diphenylpropyl)amide 
• 441788-50-7 (R_S,1R,3S)-2-methylpropane-2-sulfinic acid (3-hydroxy-1,3-diphenylpropyl)amide 
• 42052-51-7 (S)-3-hydroxy-1,3-diphenyl-propan-1-one 
• 196929-78-9 (R)-2-methylpropane-2-sulfinamide 

Relevant articles and documents

Development and application of a new general method for the asymmetric synthesis of syn- and anti-1,3-amino alcohols

A general method is described for asymmetric synthesis of both syn- and anti-1,3-amino alcohols. The first application of metalloenamines derived from N-sulfinyl imines is reported for the highly diastereoselective addition to aldehydes. The reduction of the product β-hydroxy N-sulfinyl imines 2 with catecholborane and LiBHEt3 provides syn- and anti-1,3-amino alcohols with very high diastereomeric ratios. This method was found to be effective for a variety of substrates incorporating either aromatic or various aliphatic substituents. The convergent and efficient asymmetric syntheses of the two natural products, (-)-8-epihalosaline and (-)-halosaline, were also accomplished.