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442-16-0

442-16-0

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442-16-0 Usage

Description

2-ETHOXY-6,9-DIAMINOACRIDINE is a chemical compound belonging to the acridine family, characterized by the presence of an ethoxy group at the 2nd position and two amino groups at the 6th and 9th positions. It exhibits unique chemical and biological properties, making it a potential candidate for various applications in different fields.

Uses

Used in Pharmaceutical Industry:
2-ETHOXY-6,9-DIAMINOACRIDINE is used as a pharmaceutical agent for cancer treatment. It has been found to induce a regeneration-like response in biological studies, which contributes to cancer regression. 2-ETHOXY-6,9-DIAMINOACRIDINE activates the expression and/or function of YAP and/or TAZ, key proteins involved in cell proliferation, survival, and tissue regeneration.
Used in Research Applications:
In addition to its pharmaceutical applications, 2-ETHOXY-6,9-DIAMINOACRIDINE is also utilized in research settings for studying the molecular mechanisms underlying cancer progression and regression. Its ability to modulate the expression and function of YAP and TAZ makes it a valuable tool for investigating the role of these proteins in cancer biology and potential therapeutic targets.

Purification Methods

It crystallises from 50% EtOH or EtOH as orange-yellow crystals. It also crystallises as a monohydrate m 116-118o. It has a pK2 0 of 11.04 in 50% aqueous EtOH. The methiodide is soluble in H2O and has m 332-334o (dec) (from aqueous Me2CO). [Albert & Gledhill J Soc Chem Ind 61 159 1942, Foye et al. J Pharm Sci 57 1795 1968, Albert & Goldacre J Chem Soc 708 1946, Beilstein 22 II 458, 22 III/IV 6679, 22/12 V 243.]

Check Digit Verification of cas no

The CAS Registry Mumber 442-16-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,4 and 2 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 442-16:
(5*4)+(4*4)+(3*2)+(2*1)+(1*6)=50
50 % 10 = 0
So 442-16-0 is a valid CAS Registry Number.
InChI:InChI=1/C15H15N3O/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13/h3-8H,2,16H2,1H3,(H2,17,18)

442-16-0Relevant articles and documents

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Foye et al.

, p. 1793,1795 (1968)

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