442-31-9Relevant articles and documents
Preparation method of 2-fluoroethylamine hydrochloride
-
Paragraph 0021-0023; 0025-0026; 0028-0029, (2021/04/14)
The invention discloses a preparation method of 2-fluoroethylamine hydrochloride. The method comprises the following steps: S1, synthesis of 2-fluoroethyl phthalimide: adding 2-fluoro-1-haloethane and phthalimide potassium into a reaction container, performing dissolving with N,N-dimethylformamide under mechanical stirring, performing reacting, carrying out reduced pressure distillation to recover N,N-dimethylformamide after the reaction is finished, adding water into the reaction container, performing heating and stirring, and performing cooling, filtering and vacuum drying to obtain a 2-fluoroethyl phthalimide intermediate; and S2, synthesis of the 2-fluoroethylamine hydrochloride: adding the 2-fluoroethyl phthalimide intermediate prepared in the step S1 into the reaction container, performing dissolving with ethanol, dropwise adding hydrazine hydrate for reaction, performing cooling after the reaction is finished, adjusting the pH to 5 with hydrochloric acid, performing refluxing for 1 hour, and performing filtering and vacuum drying to obtain white flaky crystal 2-fluoroethylamine hydrochloride. The method is simple in process, green, safe, low in cost and high in yield.
Deoxyfluorination of alcohols with aryl fluorosulfonates
Fei, Zhongbo,Hu, Jinbo,Li, Wei,Liu, Qinghe,Ni, Chuanfa,Wang, Xiu,Zhou, Min
supporting information, p. 8170 - 8173 (2021/08/23)
Aryl fluorosulfonates are developed as a deoxyfluorinating reagent in the transformation of primary and secondary alcohols into the corresponding alkyl fluorides. These reagents feature easy availability, low-cost, high stability and high efficiency. Diverse functionalities including aldehyde, ketone, ester, halogen, nitro, alkene, and alkyne are well tolerated under mild reaction conditions.
Silver-catalyzed decarboxylative fluorination of aliphatic carboxylic acids in aqueous solution
Yin, Feng,Wang, Zhentao,Li, Zhaodong,Li, Chaozhong
supporting information; experimental part, p. 10401 - 10404 (2012/08/08)
Although fluorinated compounds have found widespread applications in the chemical and materials industries, general and site-specific C(sp3)-F bond formations are still a challenging task. We report here that with the catalysis of AgNO3, various aliphatic carboxylic acids undergo efficient decarboxylative fluorination with SELECTFLUOR reagent in aqueous solution, leading to the synthesis of the corresponding alkyl fluorides in satisfactory yields under mild conditions. This radical fluorination method is not only efficient and general but also chemoselective and functional-group- compatible, thus making it highly practical in the synthesis of fluorinated molecules. A mechanism involvinig Ag(III)-mediated single electron transfer followed by fluorine atom transfer is proposed for this catalytic fluorodecarboxylation.