4420-46-6Relevant articles and documents
Cyclometalated cinchophen ligands on iridium(iii): Towards water-soluble complexes with visible luminescence
Smith, Rebecca A.,Stokes, Emily C.,Langdon-Jones, Emily E.,Platts, James A.,Kariuki, Benson M.,Hallett, Andrew J.,Pope, Simon J. A.
, p. 10347 - 10357 (2013)
Eight cationic heteroleptic iridium(iii) complexes, [Ir(epqc) 2(N^N)]+, were prepared in high yield from a cyclometalated iridium bridged-chloride dimer bearing two ethyl-2- phenylquinoline-4-carboxylate (epqc) ligands. Two X-ray cry
Design and synthesis of novel quinoline/chalcone/1,2,4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAFV600E kinases
Mohassab, Aliaa M.,Hassan, Heba A.,Abdelhamid, Dalia,Gouda, Ahmed M.,Youssif, Bahaa G.M.,Tateishi, Hiroshi,Fujita, Mikako,Otsuka, Masami,Abdel-Aziz, Mohamed
, (2020/12/07)
New quinoline / chalcone hybrids containing 1,2,4-triazole moiety have been designed, synthesized and their structures elucidated and confirmed by various spectroscopic techniques. The designed compounds showed moderate to good activity on different NCI 60 cell lines in a single-dose assay with a growth inhibition rate ranging from 50% to 94%. Compounds 7b, 7d, 9b, and 9d were the most active compounds in most cancer cell lines with a growth inhibition percent between 77% and 94%. Newly synthesized hybrids were evaluated for their anti-proliferative activity against a panel of four human cancer cell lines. Compounds 7a, 7b, 9a, 9b, and 9d showed promising antiproliferative activities. These compounds were further tested for their inhibitory potency against EGFR and BRAFV600E kinases with erlotinib as a reference drug. The molecular docking study of compounds 7a, 7b, 9a, 9b, and 9d revealed nice fitting into the active site of EGFR and BRAFV600E kinases. Compounds 7b, 9b, and 9d displayed the highest binding affinities and similar binding pattern to those of erlotinib.
Palladium-Catalyzed Three-Component Cascade Reaction of Nitriles: Synthesis of 2-Arylquinoline-4-carboxylates
Zhao, Zhiwei,Zeng, Ge,Chen, Yinan,Zheng, Jinming,Chen, Zhongyan,Shao, Yinlin,Zhang, Fangjun,Chen, Jiuxi,Li, Renhao
, p. 7955 - 7960 (2021/10/20)
A new method for converting easy availability starting materials 2-(2-oxoindolin-3-yl)acetonitrile, arylboronic acids, and alcohols into 2-arylquinoline-4-carboxylates is reported. The procedure involves a three-component addition/ring expansion/esterification reaction in the presence of Pd(II) catalyst with high functional group tolerance under mild conditions. In addition, the photophysical properties of the resulting product were investigated and exhibited excellent polarity-sensitive fluorescence properties and AIE property.
Ethyl lactate-involved three-component dehydrogenative reactions: Biomass feedstock in diversity-oriented quinoline synthesis
Wan, Jie-Ping,Yang, Lu
, p. 3074 - 3078 (2020/06/25)
Three-component reactions of ethyl/methyl lactate, anilines and aldehydes providing quinolines have been developed via simple iron(iii) chloride catalysis without using an additional organic medium or external oxidant. This three-component protocol shows
