4421-09-4

Basic information

• Product Name: Piperonylonitrile
• Synonyms: 5-Cyano-1,3-benzodioxole;Piperonylonitrile, 97% 25GR;3,4-Methylenedioxy benzonitrile (Piperonyl Nitrile);Piperonylonitrile 97%;3,4-Methylenedioxy benzonitrile Piperonylonitrile;2H-1,3-benzodioxole-5-carbonitrile;AKOS B004105;AKOS 214-97
• CAS NO: 4421-09-4
• Molecular Formula: C₈H₅NO₂
• Molecular Weight: 147.13
• EINECS: 224-590-6
• Product Categories: Benzodiozoles, Benzodioxines & Benzodioxepines;Benzodiozoles, Benzodioxines & Benzodioxepines;Aromatic Esters
• Mol File: 4421-09-4.mol
• Article Data: 143

Chemical Properties

• Melting Point: 91-93 °C(lit.)
• Boiling Point: 267.22°C (rough estimate)
• Flash Point: 115.4 °C
• Appearance: White to beige/Crystalline Powder or Needles
• Density: 1.3067 (rough estimate)
• Vapor Pressure: 0.0146mmHg at 25°C
• Refractive Index: 1.5510 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Dichloromethane, Ethyl Acetate, Methanol
• BRN: 6224
• CAS DataBase Reference: Piperonylonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: Piperonylonitrile(4421-09-4)
• EPA Substance Registry System: Piperonylonitrile(4421-09-4)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-20/21
• Safety Statements: 36-23-24/25
• RIDADR: 3276
• WGK Germany: 3
• RTECS: TO2645000
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 4421-09-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 4421-09-4 differently. You can refer to the following data:
1. A methylenedioxyphenyl (MDP) compound. Inhibitor of nasal P 450-dependent N-demethylase in rabbits. Toxic against D. farinae, D. pteronyssinus, and T. putrescentiae.
2. Piperonylonitrile has been used to alter the growth of Nif + and Nif - strains of K.pneumoniae.

InChI:InChI=1/C8H5NO2/c9-4-6-1-2-7-8(3-6)11-5-10-7/h1-3H,5H2

Upstream product

• 87095-03-2 5-(2-nitropropyl)benzo[d][1,3]dioxole 
• 120-57-0 piperonal 
• 274-09-9 Methylenedioxybenzene 
• 25054-53-9 3,4-(methylenedioxy)benzoyl chloride 
• 2089-36-3 piperonal oxime 
• 2635-13-4 1,2-(methylenedioxy)-4-bromobenzene 
• 544-92-3 copper(I) cyanide 
• 495-76-1 piperonol 
• 107-13-1 acrylonitrile 
• 14371-16-5 piperonal N,N-dimethylhydrazone 
• 60-29-7 diethyl ether 
• 61077-55-2 piperonal-((Z)-O-acetyl oxime ) 
• 61077-55-2 (E)-benzo[d][1,3]dioxole-5-carbaldehyde O-acetyl oxime 
• 7664-41-7 ammonia 

Downstream Products

• 3162-29-6 1-(benzo[d][1,3]dioxol-6-yl)ethanone 
• 40288-65-1 1-(benzo[1,3]dioxol-5-yl)-2-bromoethanone 
• 1027322-10-6 [3-Benzo[1,3]dioxol-5-yl-1-hydroxymethyl-4-(4-methanesulfonyl-phenyl)-cyclopent-3-enyl]-methanol 
• 1025927-52-9 3-Benzo[1,3]dioxol-5-yl-4-(4-methanesulfonyl-phenyl)-cyclopent-3-ene-1,1-dicarboxylic acid dimethyl ester 
• 1026923-41-0 C₃₅H₃₄O₁₀S₃ 
• 5423-17-6 2-benzo[1,3]dioxol-5-yl-4-methyl-thiazole 
• 145737-10-6 4-(2-benzo[1,3]dioxol-5-yl-thiazol-4-yl)-pyrocatechol 
• 248249-56-1 2-(benzo[3,4-d]1,3-dioxolan-5-yl)-4-hydroxymethyl-1,3-thiazole 
• 248249-53-8 ethyl 4-(benzo[3,4-d]1,3-dioxolan-5-yl)-3,5-thiazole carboxylate 
• 2620-50-0 1,3-benzodioxol-5-ylmethyl amine 
• 6701-35-5 bis(benzo[d][1,3]dioxol-5-ylmethyl)amine 
• 82-85-9 benzo[1,3]dioxol-5-yl-(2-hydroxy-4,6-dimethoxy-phenyl)-ketone 
• 17345-61-8 3,4-dihydroxybenzonitrile 
• 177662-29-2 3,4-methylenedioxy-N-[4-(methylsulfonyl)phenyl]benzenecarboximidamide 

Relevant articles and documents

Imidazole hydrochloride promoted synthesis of 3,5-disubstituted-1,2,4-oxadiazoles

Imidazole hydrochloride as an additive promotes the reaction of amidoximes and DMA derivatives to generated 3,5-disubstituted-1,2,4-oxadiazoles in low to excellent yields without the use of coupling reagents, oxidants, strong acids or bases and other additives.

CuO-catalyzed conversion of arylacetic acids into aromatic nitriles with K4Fe(CN)6 as the nitrogen source

Readily available CuO was demonstrated to be effective as the catalyst for the conversion of arylacetic acids to aromatic nitriles with non-toxic and inexpensive K4Fe(CN)6 as the nitrogen source via the complete cleavage of the C[tbnd]N triple bond. The present method allowed a series of arylacetic acids including phenylacetic acids, naphthaleneacetic acids, 2-thiopheneacetic acid and 2-furanacetic acid to be converted into the targeted products in low to high yields.

Selective oxidation of alcohols to nitriles with high-efficient Co-[Bmim]Br/C catalyst system

An efficient method for catalyzing the ammoxidation of aromatic alcohols to aromatic nitriles was developed, in which a new heterogeneous catalyst based on transition metal elements was employed, the new catalyst was named Co-[Bmim]Br/C-700 and then characterized by X-ray photo-electronic spectroscopy, transmission electron microscope and X-ray diffraction. The reaction was carried out by two consecutive dehydrogenations under the catalysis of Co-[Bmim]Br/C-700, which catalytically oxidized the alcohol to the aldehyde, and then the aldehyde was subjected to ammoxidation to the nitrile. The catalyst system was suitable for a wide range of substrates and nitriles obtained in high yields, especially, the conversion rate of benzyl alcohol, 4-methoxybenzyl alcohol, 4-chlorobenzyl alcohol and 4-nitrobenzyl alcohol reached 100%. The substitution of ammonia and oxygen for toxic cyanide to participate in the reaction accords with the theory of green chemistry.