442125-04-4 Usage
Description
6-Chloro-2-benzofuran carboxylic acid is an organic compound characterized by the presence of a benzofuran ring with a chloro substituent at the 6-position and a carboxylic acid group at the 2-position. This chemical structure endows it with unique properties that make it a versatile building block in the synthesis of various pharmaceutical agents.
Uses
Used in Pharmaceutical Industry:
6-Chloro-2-benzofuran carboxylic acid is used as a key intermediate in the synthesis of cis-diaminocyclohexane derivatives, which are known as factor Xa inhibitors. These inhibitors play a crucial role in the prevention of blood clot formation, making them valuable in the development of anticoagulant drugs for the treatment of thrombotic disorders.
Additionally, 6-chloro-2-benzofuran carboxylic acid is utilized in the synthesis of tachykinin NK2 receptor antagonists. These antagonists are important in the development of drugs targeting the neurokinin receptor system, which is involved in various physiological processes, including pain transmission, inflammation, and smooth muscle contraction. By modulating the activity of the NK2 receptor, these antagonists have potential applications in the treatment of conditions such as asthma, chronic obstructive pulmonary disease (COPD), and irritable bowel syndrome (IBS).
Check Digit Verification of cas no
The CAS Registry Mumber 442125-04-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,2,1,2 and 5 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 442125-04:
(8*4)+(7*4)+(6*2)+(5*1)+(4*2)+(3*5)+(2*0)+(1*4)=104
104 % 10 = 4
So 442125-04-4 is a valid CAS Registry Number.
442125-04-4Relevant articles and documents
Synthesis and biological evaluation of a series of novel benzofuran-2-carboxylate 1,2,3-triazoles
Bhaskar, K.,Yadav, J. S.
, p. 767 - 774 (2021/09/28)
A facile and efficient synthetic route has been developed to substituted benzofuran-2-carboxylate 1,2,3-triazoles for the first time by reacting prop-2-yn-1-yl benzofuran-2-carboxylate with a variety of substituted aryl/benzyl azides in DMF/H2O system employing standard click reaction. This new method has the lead of good yields, inexpensive reagents, easily available, easy work-up, mild reaction conditions, and environmentally friendly reaction conditions. All these compounds have been characterized by modern spectral techniques such as IR, 1H NMR, and mass spectroscopy, etc. Evaluation of synthesized compounds for antimicrobial activity against specific bacterial strains like Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa along with antifungal activity against Aspergillus Niger and Sclerotium rolfsii have been carried out.
GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES
-
Paragraph 0001277, (2015/04/15)
Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).
