442517-33-1 Usage
General Description
6-Ethyynylquinoxaline is an organic compound with the chemical formula C10H6N2. It is a yellowish-brown solid with a melting point of 88-89 degrees Celsius. 6-Ethyynylquinoxaline is commonly used as a building block in the synthesis of various biologically active molecules and pharmaceutical compounds. It is also used in the field of material science for the development of organic electronic devices such as organic light-emitting diodes (OLEDs) and organic photovoltaic cells. Additionally, it has been studied for its potential applications in the field of organic synthesis and chemistry research due to its unique chemical reactivity and diverse functional group compatibility.
Check Digit Verification of cas no
The CAS Registry Mumber 442517-33-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,2,5,1 and 7 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 442517-33:
(8*4)+(7*4)+(6*2)+(5*5)+(4*1)+(3*7)+(2*3)+(1*3)=131
131 % 10 = 1
So 442517-33-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H6N2/c1-2-8-3-4-9-10(7-8)12-6-5-11-9/h1,3-7H
442517-33-1Relevant articles and documents
Design, synthesis, and evaluation of hinge-binder tethered 1,2,3-triazolylsalicylamide derivatives as Aurora kinase inhibitors
Jeong, Yunkyung,Lee, Jooyeon,Ryu, Jae-Sang
, p. 2114 - 2124 (2016)
A series of hinge-binder tethered 1,2,3-triazolylsalicylamide derivatives were designed, synthesized, and evaluated for the Aurora kinase inhibitory activities. The novel hinge-binder tethered 1,2,3-triazolylsalicylamide scaffold was effectively assembled by Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC). A variety of alkynes with hinge binders were used to search proper structures-binding relationship to the hinge region. The synthesized 1,2,3-triazolylsalicylamide derivatives showed significant Aurora kinase inhibitory activity. In particular, 8a inhibited Aurora A kinase with an IC50 value of 0.284 μM, whereas 8m inhibited Aurora B kinase with an IC50 value of 0.364 μM.
