442669-65-0

Basic information

• Product Name: Benzamide, N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-
• CAS NO: 442669-65-0
• Molecular Formula: C17H19NO2
• Molecular Weight: 269.343
• Mol File: 442669-65-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-(442669-65-0)
• EPA Substance Registry System: Benzamide, N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-(442669-65-0)

Safety Data

• Hazardous Substances Data: 442669-65-0(Hazardous Substances Data)

Upstream product

• 90-82-4 pseudoephedrine 
• 127033-85-6 1-(3,4,5-trimethoxyphenyl)-3-phenylprop-2-yn-1-one 
• 55116-41-1 2-(N-benzoyl-N-methylamino)-1-phenyl-1-propanone 

Relevant articles and documents

Reaction of α,β-alkynylketones with β-amino alcohols: Pseudoephedrine- assisted cleavage of triple bond via formal internal redox process

Reaction of 3-aryl-1-(3,4,5-trimethoxyphenyl)prop-2-yn-1-ones with (+)-pseudoephedrine leads to products of alkyne moiety cleavage, namely, 1-(3,4,5-trimethoxyphenyl)ethanone and N-(1-hydroxy-1-phenylprop-2-yl)-N-methylbenzamides. In the course of the process one of alkyne carbons undergoes a formal reduction to a Me group, whereas the other one is oxidized to a C(O)NRR' moiety.

Polymer-immobilized catalyst for asymmetric hydrogenation of racemic α-(N-benzoyl-N-methylamino)propiophenone

Asymmetric hydrogenation of α-(N-benzoyl-N-methylami-no)propiophenone through dynamic kinetic resolution was performed by using a polymer-immobilized chiral diamine-ruthenium-BINAP-t-BuOK system in order to yield syn-β-amidealcoholexclusivelywithnearlyperfectenantioselectivity.