443-84-5 Usage
Description
2,6-Difluorotoluene is an organic compound that consists of a toluene molecule with two fluorine atoms attached to the 2nd and 6th carbon positions. It is a colorless liquid with a distinctive aromatic smell. The presence of fluorine atoms in the molecule imparts unique chemical and physical properties, making it a versatile intermediate in various chemical reactions and applications.
Uses
Used in Chemical Synthesis:
2,6-Difluorotoluene is used as a chemical intermediate for the synthesis of various fluorinated compounds. The presence of fluorine atoms in the molecule makes it a valuable building block for the production of pharmaceuticals, agrochemicals, and specialty chemicals.
Used in Spectroscopy Research:
2,6-Difluorotoluene is used as a precursor to generate jet-cooled 2,6-difluorobenzyl radicals, which are employed to investigate their vibronically resolved emission spectra. This research helps in understanding the electronic structure and properties of these radicals, which can be useful in various applications, such as the development of new materials and the study of chemical reactions.
Used in the Production of Fluoropolymers:
2,6-Difluorotoluene can be used as a monomer in the production of fluoropolymers, which are known for their excellent chemical resistance, thermal stability, and non-stick properties. These polymers find applications in various industries, such as automotive, aerospace, electronics, and coatings.
Used in the Synthesis of Fluorinated Aromatics:
2,6-Difluorotoluene can be further functionalized to produce a range of fluorinated aromatic compounds, which are used as intermediates in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. These fluorinated aromatics exhibit unique properties, such as enhanced lipophilicity and metabolic stability, making them valuable in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 443-84-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,4 and 3 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 443-84:
(5*4)+(4*4)+(3*3)+(2*8)+(1*4)=65
65 % 10 = 5
So 443-84-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H8FN/c1-5-6(8)3-2-4-7(5)9/h2-4H,9H2,1H3
443-84-5Relevant articles and documents
Sulfonyl chloride as a disposable electron withdrawing substituent in halex fluorinations
Kageyama, Hiroyuki,Suzuki, Hiroshi,Kimura, Yoshikazu
, p. 85 - 89 (2007/10/03)
Syntheses of 1,3-difluorobenzene and 2,6-difluorotoluene are described via chlorosulfonation, catalytic Halex-fluorination, and desulfination of 1,3-dichlorobenzene and 2,6-dichlorotoluene.
REACTIONS OF AROMATIC COMPOUNDS WITH NUCLEOPHILIC REAGENTS IN LIQUID AMMONIA. REACTION OF POLYFLUORINATED DERIVATIVES OF BENZENE WITH SODIUM AMIDE
Shtark, A. A.,Chuikova, T. V.,Selivanova, G. A.,Shteingarts, V. D.
, p. 2271 - 2276 (2007/10/02)
Under the influence of sodium amide in liquid ammonia at a temperature no higher than -33 deg C pentafluorobenzene, 1,2,4,5-tetrafluorobenzene, and 1,3-difluorobenzene undergo deprotonation with the formation of fluorinated phenyl anions, which are resistant to the elimination of a fluoride ion and can be detected by the formation of the products from interaction with electrophiles (with the initial compound in the first case and with methyl iodide in the other two cases). 1,3,5-Trifluorobenzene behaves similarly in reaction with one equivalent of sodium amide, but with two equivalents of sodium amide this compound and 1,2,3,5-tetrafluorob enzene undergo substitution of a fluorine atom by an amino group with the formation of 3,5-di- and 3,4,5-trifluoroanilines respectively.This is clearly due to the double deprotonation of these compounds with the formation of polyfluorinated m-phenylene dianions, which are then converted with the elimination of a fluoride ion into the corresponding dehydrophenyl anions.
The synthesis of ortho-substituted 2-diethylaminoethyl benzoates as potential local anaesthetics.
THOMAS,CANTY
, p. 587 - 596 (2007/10/05)
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