443331-76-8

Basic information

• Product Name: {5-[(4-benzyloxycarbonylamino-benzylcarbamoyl)-methyl]-6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl}-acetic acid methyl ester
• CAS NO: 443331-76-8
• Molecular Weight: 577.637
• Mol File: 443331-76-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {5-[(4-benzyloxycarbonylamino-benzylcarbamoyl)-methyl]-6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl}-acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {5-[(4-benzyloxycarbonylamino-benzylcarbamoyl)-methyl]-6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl}-acetic acid methyl ester(443331-76-8)
• EPA Substance Registry System: {5-[(4-benzyloxycarbonylamino-benzylcarbamoyl)-methyl]-6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl}-acetic acid methyl ester(443331-76-8)

Safety Data

• Hazardous Substances Data: 443331-76-8(Hazardous Substances Data)

Upstream product

• 326404-44-8 methyl [5-(2-tert-butoxy-2-oxoethyl)-6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl]acetate 
• 326404-40-4 methyl (E,Z)-[5-(2-tert-butoxy-2-oxoethyl)-6-oxo-5,6-dihydro-11H-dibenzo[b,e]azepin-11-ylidene]acetate 
• 90664-74-7 methyl (6-oxo-5,6-dihydro-11H-dibenzo-[b,e]azepin-11-ylidene)-acetate 
• 443331-14-4 4-(aminomethyl)-N-(benzyloxycarbonyl)phenylamine 
• 326404-49-3 11-(2-methoxy-2-oxoethyl)-6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-5-yl acetic acid 
• 84-65-1 9,10-phenanthrenequinone 
• 1143-50-6 5,6-dihydro-6,11-dioxomorphanthridine 

Relevant articles and documents

Synthesis and SAR of N-substituted dibenzazepinone derivatives as novel potent and selective αVβ3 antagonists

Synthesis and SARs of new integrin αVβ3 antagonists based on an N-substituted dibenzazepinone scaffold are described. Variation of spacer and guanidine mimetic led to potent compounds exhibiting an IC50 towards αVβ3 in the nanomolar range, high selectivity versus integrin αIIbβ3 and efficacy in functional cellular assays.