4435-67-0

Basic information

• Product Name: 1 3 5-BENZENETRIACETIC ACID
• Synonyms: 1,3,5-tris(carboxymethyl)benzene;benzene-1,3,5-triacetic acid;2,2',2''-(benzene-1,3,5-triyl)triacetic acid;Benzene-1,3,5-triacetic acid >=97.0% (T);2-[3,5-Bis(carboxymethyl)phenyl]acetic acid
• CAS NO: 4435-67-0
• Molecular Formula: C₁₂H₁₂O₆
• Molecular Weight: 252.22
• Mol File: 4435-67-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 210-215 °C
• Boiling Point: 534.2°Cat760mmHg
• Flash Point: 291°C
• Appearance: /
• Density: 1.468g/cm³
• BRN: 9300288
• CAS DataBase Reference: 1 3 5-BENZENETRIACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1 3 5-BENZENETRIACETIC ACID(4435-67-0)
• EPA Substance Registry System: 1 3 5-BENZENETRIACETIC ACID(4435-67-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 4435-67-0(Hazardous Substances Data)

Usage

General Description

1 3 5-BenzeneTriacetic Acid, also known as Benzene-1,3,5-triacetic acid, is an aromatic compound composed of a benzene ring with three acetic acid groups attached to it. The presence of these acetic acid groups makes it a triprotic acid, meaning it can donate three protons. This particular structure gives the compound its unique acidic properties. It is a synthetic compound that is not naturally occurring. This chemical is primarily used in various applications in chemical industries, including as an intermediate in synthesis.

Upstream product

• 18226-42-1 1,3,5-Tris(bromomethyl)benzene 
• 7567-63-7 1,3,5-Triethynylbenzene 
• 17299-97-7 α,α',α''-trichloromesitylene 
• 779-90-8 1,3,5-triacetylbenzene 

Downstream Products

• 859032-83-0 benzene-1,3,5-triyl-tri-acetic acid triethyl ester 
• 110059-69-3 benzene-1,3,5-triyl-tri-acetic acid tris-(2-bromo-ethyl ester) 
• 77354-22-4 1,3,5-benzene-triacetyl chloride 
• 85294-18-4 1,3,5-tris(carboxymethyl-α,α-d2)benzene 
• 204263-36-5 2-(3,5-Bis-but-3-ynylcarbamoylmethyl-phenyl)-N-but-3-ynyl-acetamide 
• 18226-43-2 1,3,5-benzenetriethanol 
• 18226-47-6 1,3,5-tris(2'-bromoethyl)benzene 
• 80935-59-7 2,2',2''-(benzene-1,3,5-triyl)triacetonitrile 
• 3002-81-1 5, 6-dimethyl-1,10-phenanthroline 

Relevant articles and documents

Antibiotic Conjugates with an Artificial MECAM-Based Siderophore Are Potent Agents against Gram-Positive and Gram-Negative Bacterial Pathogens

The development of novel drugs against Gram-negative bacteria represents an urgent medical need. To overcome their outer cell membrane, we synthesized conjugates of antibiotics and artificial siderophores based on the MECAM core, which are imported by bacterial iron uptake systems. Structures, spin states, and iron binding properties were predicted in silico using density functional theory. The capability of MECAM to function as an effective artificial siderophore in Escherichia coli was proven in microbiological growth recovery and bioanalytical assays. Following a linker optimization focused on transport efficiency, five β-lactam and one daptomycin conjugates were prepared. The most potent conjugate 27 showed growth inhibition of Gram-positive and Gram-negative multidrug-resistant pathogens at nanomolar concentrations. The uptake pathway of MECAMs was deciphered by knockout mutants and highlighted the relevance of FepA, CirA, and Fiu. Resistance against 27 was mediated by a mutation in the gene encoding ExbB, which is involved in siderophore transport.

Preparation method of acid with different substituent groups

The invention discloses a preparation method of an acid with different substituent groups. A terminal alkyne is lithiated with n-butyllithium, and then reacts with isopropoxyboronic acid pinacol ester, hydrogen chloride is added to achieve quenching, then the obtained reaction product is oxidized by an oxidizing agent, and the oxidized reaction product is separated and purified to obtain the acid.The method of the invention has the advantages of simplicity in operation, one-pot process preparation, no metal catalysis, nontoxic reagents, greenness, environmental friendliness and high atomic utilization rate, and provides a novel and quick way for preparing the acid with different substituent groups; and the obtained acid is an important fine chemical product, and can be widely used in fields of medicines, pesticides, spices and other industries.