4439-56-9

Basic information

• Product Name: NSC97553
• Synonyms: NSC97553;2-furylmethyl(phenyl)amine;N-(2-Furanylmethyl)aniline;N-Phenylfurfurylamine;N-(furan-2-ylmethyl) aniline analogue
• CAS NO: 4439-56-9
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.214
• Mol File: 4439-56-9.mol
• Article Data: 133

Chemical Properties

• Boiling Point: 281 °C at 760 mmHg
• Flash Point: 123.7 °C
• Appearance: /
• Density: 1.136 g/cm³
• Vapor Pressure: 0.00366mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: NSC97553(CAS DataBase Reference)
• NIST Chemistry Reference: NSC97553(4439-56-9)
• EPA Substance Registry System: NSC97553(4439-56-9)

Safety Data

• Hazardous Substances Data: 4439-56-9(Hazardous Substances Data)

Usage

General Description

NSC97553, also known as JNJ-26854165, is a small molecule inhibitor of the human sirtuin 1 (SIRT1) enzyme. SIRT1 is a protein deacetylase that is involved in a variety of cellular processes, including regulation of gene expression, DNA repair, and metabolism. NSC97553 has been studied for its potential as a cancer therapy due to its ability to induce apoptosis and inhibit cell proliferation in various cancer cell lines. It has also been investigated for its anti-inflammatory and neuroprotective effects. Research on NSC97553 is ongoing, and its potential as a therapeutic agent for various diseases continues to be explored.

InChI:InChI=1/C11H11NO/c1-2-5-10(6-3-1)12-9-11-7-4-8-13-11/h1-8,12H,9H2

Upstream product

• 4437-18-7 2-bromomethylfuran 
• 62-53-3 aniline 
• 3237-23-8 N-(2-furylmethylene)aniline 
• 98-01-1 furfural 
• 120474-86-4 (E)-N-furfurylideneaniline 
• 98-00-0 (2-furyl)methyl alcohol 
• 2325-27-1 N-phenyltriphenyliminophosphorane 
• 108-44-1 1-amino-3-methylbenzene 
• 617-89-0 furan-2-ylmethanamine 
• 100-68-5 methyl-phenyl-thioether 
• 98-95-3 nitrobenzene 
• 538-51-2 benzylidene phenylamine 
• 103-84-4 Acetanilid 
• 88-14-2 2-furanoic acid 

Downstream Products

• 182358-29-8 6-(Furan-2-ylmethyl-phenyl-amino)-3-methyl-5-(phenyl-hydrazonomethyl)-1H-pyrimidine-2,4-dione 
• 953065-28-6 4-(((furan-2-ylmethyl)(phenyl)amino)methyl)quinolin-2(1H)-one 
• 4481-57-6 (tetrahydrofuran-2-ylmethyl)-phenylamine 

Relevant articles and documents

Furfural and 5-(hydroxymethyl)furfural valorization using homogeneous Ni(0) and Ni(II) catalysts by transfer hydrogenation

The complex [dippeNi(COD)] (dippe =1,2-bis(diisopropyl phosphino)ethane) was used as a catalytic precursor in furfural (FF) and 5-(hydroxymethyl)furfural (HMF) valorization, along with formic acid as hydrogen transfer agent, to produce the corresponding a

BF3·Et2O as a metal-free catalyst for direct reductive amination of aldehydes with amines using formic acid as a reductant

A versatile metal- and base-free direct reductive amination of aldehydes with amines using formic acid as a reductant under the catalysis of inexpensive BF3·Et2O has been developed. A wide range of primary and secondary amines and diversely substituted aldehydes are compatible with this transformation, allowing facile access to various secondary and tertiary amines in high yields with wide functional group tolerance. Moreover, the method is convenient for the late-stage functionalization of bioactive compounds and preparation of commercialized drug molecules and biologically relevant N-heterocycles. The procedure has the advantages of simple operation and workup and easy scale-up, and does not require dry conditions, an inert atmosphere or a water scavenger. Mechanistic studies reveal the involvement of imine activation by BF3and hydride transfer from formic acid.

Palladium supported on magnesium hydroxyl fluoride: An effective acid catalyst for the hydrogenation of imines and N-heterocycles

Palladium catalysts supported on acidic fluorinated magnesium hydroxide Pd/MgF2-x(OH)x were prepared through precipitation or impregnation methods. Applications to the hydrogenation of various aldimines and ketimines resulted in good catalytic activities at mild temperatures using one atmosphere of hydrogen. Quinolines, pyridines and other N-heterocycles were successfully hydrogenated at higher temperature and hydrogen pressure using low palladium loadings and without the use of any acid additive. Such reactivity trend confirmed the positive effect of the Br?nsted and Lewis acid sites from the fluorinated magnesium hydroxide support resulting in the effective pre-activation of N-heterocycle substrates and therefore in the good catalytic activity of the palladium nanoparticles during the hydrogenations. As demonstrated in the hydrogenation of imines, the catalyst was recycled up to 10 times without either loss of activity or palladium leaching. This journal is