444341-80-4

Basic information

• Product Name: 2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL
• Synonyms: 2-CHLORO-4-(TRIFLUOROETHOXY)-PHENOL;2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL
• CAS NO: 444341-80-4
• Molecular Formula: C₈H₆ClF₃O₂
• Molecular Weight: 226.58
• Product Categories: Phenol&Thiophenol&Mercaptan
• Mol File: 444341-80-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 243.382 °C at 760 mmHg
• Flash Point: 100.994 °C
• Appearance: /
• Density: 1.446 g/cm³
• Vapor Pressure: 0.021mmHg at 25°C
• Refractive Index: 1.484
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL(444341-80-4)
• EPA Substance Registry System: 2-CHLORO-4-(2,2,2-TRIFLUOROETHOXY)PHENOL(444341-80-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 444341-80-4(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-(2,2,2-trifluoroethoxy)phenol, also known as Triclosan, is a synthetic chemical compound commonly used as an antibacterial and antifungal agent in a variety of personal care products such as soaps, toothpaste, and hand sanitizers. It is also used in medical devices, textiles, and plastics. Triclosan works by inhibiting the growth of bacteria and fungi, making it effective in preventing odors and the spread of infections. However, its widespread use has raised concerns about its environmental impact and potential health risks. Studies have shown that Triclosan can accumulate in the environment and marine life, and may have negative effects on hormone functioning and resistance to antibiotics. As a result, several countries have banned or restricted the use of Triclosan in certain products.

InChI:InChI=1/C8H6ClF3O2/c9-6-3-5(1-2-7(6)13)14-4-8(10,11)12/h1-3,13H,4H2

Upstream product

• 129560-99-2 4-(2,2,2-trifluoroethoxy)phenol 
• 110-96-3 diisobutylamine 
• 103-16-2 4-Benzyloxyphenol 
• 200956-20-3 1-(benzyloxy)-4-(2,2,2-trifluoroethoxy)benzene 

Downstream Products

• 653578-09-7 5-{3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-phenoxy]-propoxy}-2-methyl-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester 
• 653578-14-4 3-[2-chloro-4-(2,2,2-trifluoroethoxy)phenoxy]propyl iodide 
• 653578-08-6 3-[2-chloro-4-(2,2,2-trifluoro-ethoxy)-phenoxy]-propan-1-ol 
• 444341-81-5 3-bromopropyl 2-chloro-4-(2,2,2-trifluoroethoxy)phenyl ether 

Relevant articles and documents

(2R)-2-Methylchromane-2-carboxylic acids: Discovery of selective PPARα agonists as hypolipidemic agents

A SAR study was conducted on chromane-2-carboxylic acid toward selective PPARα agonisim. As a result, highly potent, and selective PPARα agonists were discovered. The optimized compound 43 exhibited robust lowering of total cholesterol levels in hamster and dog animal models.

Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders

A class of benzopyrancarboxylic acid derivatives comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, d