444643-02-1

Basic information

• Product Name: (S)-1-phenyl-N-((S)-1-(2-(trifluoromethyl)phenyl)ethyl)ethanamine
• Synonyms: (S)-1-phenyl-N-((S)-1-(2-(trifluoromethyl)phenyl)ethyl)ethanamine
• CAS NO: 444643-02-1
• Molecular Weight: 293.332
• Mol File: 444643-02-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-1-phenyl-N-((S)-1-(2-(trifluoromethyl)phenyl)ethyl)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-phenyl-N-((S)-1-(2-(trifluoromethyl)phenyl)ethyl)ethanamine(444643-02-1)
• EPA Substance Registry System: (S)-1-phenyl-N-((S)-1-(2-(trifluoromethyl)phenyl)ethyl)ethanamine(444643-02-1)

Safety Data

• Hazardous Substances Data: 444643-02-1(Hazardous Substances Data)

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 17408-14-9 1-(2-(trifluoromethyl)phenyl)ethan-1-one 
• 1332827-89-0 C₈H₆O₄*C₁₇H₁₈F₃N 
• 437762-07-7 (S)-1-phenyl-N-{(S)-1-[2-(trifluoromethyl)phenyl]ethyl}ethanamine 

Downstream Products

• 127733-39-5 (S)-α-(o-(trifluoromethyl)phenyl)ethylamine 
• 1332827-99-2 (S)-2,2,2-trifluoro-N-(1-(2-(trifluoromethyl)phenyl)ethyl)acetamide 
• 865815-09-4 (S)-1-(2-(trifluoromethyl)phenyl)ethan-1-amine hydrochloride 

Relevant articles and documents

Highly regioselective hydrogenolysis of bis(α-methylbenzyl)amine derivatives affected by the trifluoromethyl substituent on the aromatic ring

(Matrix presented) The highly regioselective hydrogenolysis of bis(α-methylbenzyl)amine derivatives proceeded with influence not from the electronic effect but from the steric effect of the trifluoromethyl substituent on the aromatic ring to provide a practical asymmetric synthesis of trifluoromethyl-substituted α-phenylethylamines.

Sequential reductive amination-hydrogenolysis: A one-pot synthesis of challenging chiral primary amines

Difficult-to-access chiral primary amines were formed in good to high yield and ee using a rare example of a one-pot synthesis from prochiral ketones (sequential reductive amination-hydrogenloysis). As a highlight we also demonstrate a one-pot reductive amination-hydrogenolysis-reductive amination (five reactions) of ortho-methoxyacetophenone resulting in the chiral diamine 1-(2-methoxyphenyl)ethyl-(2-pyridylmethyl)-amine (4) (58% overall yield, >99% ee), a new organocatalyst for aqueous enantioselective aldol reactions. Copyright