445-65-8

Basic information

• Product Name: 2-fluoro-3,5-dinitrobenzoic acid
• Synonyms: 2-fluoro-3,5-dinitrobenzoic acid
• CAS NO: 445-65-8
• Molecular Weight: 230.109
• Mol File: 445-65-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-fluoro-3,5-dinitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-3,5-dinitrobenzoic acid(445-65-8)
• EPA Substance Registry System: 2-fluoro-3,5-dinitrobenzoic acid(445-65-8)

Safety Data

• Hazardous Substances Data: 445-65-8(Hazardous Substances Data)

Upstream product

• 445-29-4 o-fluoro-benzoic acid 

Downstream Products

• 330183-81-8 2-fluoro-3,5-dinitro-benzoic acid 2-trityloxy-ethyl ester 
• 18646-02-1 3.5-Dinitro-2-fluor-anilin 
• 18646-13-4 2-Fluor-3,5-dinitro-benzoylazid 
• 18646-03-2 3,5-Dinitro-2-fluor-carbanilsaeure-tert.-butylester 
• 1363983-79-2 (5S,6S,9R)-4-(2-fluoro-3,5-dinitrobenzoyl)-6-isopropyl-9-methyl-1,4-diazaspiro[4.5]decan-2-one 
• 367946-80-3 methyl 2-fluoro-3,5-dinitrobenzoic ester 
• 313681-58-2 2-(4-{(2S,3R)-2-({[(3R,3AS,6AR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-4-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-3-hydroxybutyl}phenoxy)-3,5-dinitrobenzoic Acid 
• 330184-05-9 3,5-Dinitro-2-((2S,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxy)-benzoic acid (2R,3R,4S,5R,6S)-4,5-bis-benzyloxy-3-hydroxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester 
• 367947-04-4 2,4-dinitro-6-(methoxycarbonyl)phenyl 2,3,4,6-tetra-O-benzoyl-β-D-glucopyranoside 
• 367947-02-2 2,4-dinitro-6-(methoxycarbonyl)phenyl 2,3,4,6-tetra-O-benzyl-β-D-glucopyranoside 
• 367946-88-1 2,4-dinitro-6-(methoxycarbonyl)phenyl 2,3,4,6-tetra-O-benzyl-α-D-mannopyranoside 
• 98279-87-9 2,3-diamino-5-nitrobenzoic acid 
• 872123-65-4 4-nitrophenyl 2-fluoro-3,5-dinitrobenzoate 
• 872123-64-3 isopropyl 2-fluoro-3,5-dinitrobenzoate 

Relevant articles and documents

A new, efficient glycosylation method for oligosaccharide synthesis under neutral conditions: Preparation and use of new DISAL donors

Efficient, stereoselective glycosylation methods are required for the synthesis of complex oligosaccharides as tools in glycobiology. All glycosylation methods, which have found wide acceptance, rely on Lewis acid activation of glycosyl donors prior to glycosylation. Here, we present a new and efficient method for glycosylation under neutral or mildly basic conditions. Glycosides of methyl 2-hydroxy-3,5-dinitrobenzoate (DISAL) and its para regioisomer, methyl 4-hydroxy-3,5-dinitrobenzoate, were prepared by nucleophilic aromatic substitution. In a first demonstration of their potential as glycosyl donors, stereospecific glycosylation of methanol was achieved. In the glycosylation of more hindered alcohols, the β-donor proved more reactive, and α-glucosides were predominantly formed. Glycosylation of protected monosaccharides, with free 6-0H or 3-OH, proceeded smoothly in 1-methyl-2-pyrrolidinone (NMP) at 40-60 °C in the absence of Lewis acids and bases in good to excellent yields. Glycosylation of 3-OH gave the α-linked disaccharide only.

HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE

The present invention relates to novel hydroxyethylamine compounds of formula (I): (I) having Asp2 (-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated-amyloid levels or-amyloid deposits, particularly Alzheimer's disease.