445218-61-1

Basic information

• Product Name: Topiroxostat Impurity 2
• Synonyms: Topiroxostat Impurity 2
• CAS NO: 445218-61-1
• Molecular Formula: C12H11N5O
• Molecular Weight: 241.24864
• Mol File: 445218-61-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Topiroxostat Impurity 2(CAS DataBase Reference)
• NIST Chemistry Reference: Topiroxostat Impurity 2(445218-61-1)
• EPA Substance Registry System: Topiroxostat Impurity 2(445218-61-1)

Safety Data

• Hazardous Substances Data: 445218-61-1(Hazardous Substances Data)

Upstream product

• 100-48-1 pyridine-4-carbonitrile 
• 54-85-3 isoniazid 

Downstream Products

• 4329-78-6 3,5-di(pyridin-4-yl)-1,2,4-triazole 

Relevant articles and documents

Discovery of 3-(3-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051-a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia

Our previous study identified 2-[2-(2-methoxy-ethoxy)-ethoxy]-5-[5-(2-methyl-4-pyridyl)-1H-[1,2,4]triazol-3-yl]-benzonitrile (2) as a safe and potent xanthine oxidoreductase (XOR) inhibitor for the treatment of hyperuricemia. Here, we synthesized a series of 3,5-dipyridyl-1,2,4-triazole derivatives and, in particular, examined their in vivo activity in lowering the serum uric acid levels in rats. As a result, we identified 3-(3-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole (FYX-051, compound 39) to be one of the most potent XOR inhibitors; it exhibited an extremely potent in vivo activity, weak CYP3A4-inhibitory activity and a better pharmacokinetic profile than compound 2. Compound 39 is currently being evaluated in a phase 2 clinical trial.