445288-81-3

Basic information

• Product Name: N-octyl-2-pyrazinecarboxamide
• Synonyms: N-octyl-2-pyrazinecarboxamide
• CAS NO: 445288-81-3
• Molecular Formula: C13H21N3O
• Molecular Weight: 235.32534
• Mol File: 445288-81-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-octyl-2-pyrazinecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-octyl-2-pyrazinecarboxamide(445288-81-3)
• EPA Substance Registry System: N-octyl-2-pyrazinecarboxamide(445288-81-3)

Safety Data

• Hazardous Substances Data: 445288-81-3(Hazardous Substances Data)

Upstream product

• 19847-12-2 2-pyrazine carbonitrile 
• 111-86-4 n-Octylamine 
• 98-96-4 pyrazinamide 
• 19847-10-0 pyrazinoyl chloride 
• 4744-50-7 2,3-pyrazinedicarboxylic anhydride 

Relevant articles and documents

Optimization of physicochemical properties is a strategy to improve drug-likeness associated with activity: Novel active and selective compounds against Trypanosoma cruzi

Trypanosoma cruzi is the causing agent of Chagas disease, a parasitic infection without efficient treatment for chronic patients. Despite the efforts, no new drugs have been approved for this disease in the last 60 years. Molecular modifications based on

Preparation of pyrazine carboxamides: A reaction involving N-heterocyclic carbene (NHC) intermediates

In the reactions of 2,3-pyrazinedicarboxylic anhydride with amines and anilines, pyrazine carboxamides are formed in good to excellent yields. A mechanism is proposed involving ring opening of the anhydride and decarboxylation of the heterocyclic ring. Based on other similar heterocyclic decarboxylations, this suggests the involvement of an N-heterocyclic carbene intermediate leading to the product.

Transamidation of amides with amines under solvent-free conditions using a CeO2 catalyst

Among various metal oxides, cerium oxide (CeO2) shows the highest catalytic activity for transamidation of picolinamide with n-octylamine. CeO2 acts as a reusable and effective heterogeneous catalyst for transamidation under solvent-free conditions. Transamidation of a variety of amides and amines produced the corresponding N-alkyl amides in high yields. This method provides the first example of a heterogeneous catalyst for transamidation using aliphatic amines as substrates. Characterization of acid-base properties and kinetic studies suggest that the cooperation of the weak Lewis acid sites and adjacent strong base sites play important roles in the transamidation reaction. The Royal Society of Chemistry 2012.