445298-97-5

Basic information

• Product Name: (R)-2-Benzylamino-propionic acid (1S,2S)-2-dimethylamino-1-phenyl-propyl ester
• Synonyms: (R)-2-Benzylamino-propionic acid (1S,2S)-2-dimethylamino-1-phenyl-propyl ester
• CAS NO: 445298-97-5
• Molecular Weight: 340.466
• Mol File: 445298-97-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-Benzylamino-propionic acid (1S,2S)-2-dimethylamino-1-phenyl-propyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-Benzylamino-propionic acid (1S,2S)-2-dimethylamino-1-phenyl-propyl ester(445298-97-5)
• EPA Substance Registry System: (R)-2-Benzylamino-propionic acid (1S,2S)-2-dimethylamino-1-phenyl-propyl ester(445298-97-5)

Safety Data

• Hazardous Substances Data: 445298-97-5(Hazardous Substances Data)

Upstream product

• 1201-56-5 (1S,2S)-N-Methylpseudoephedrine 
• 492-39-7 (1S,2S)-2-amino-1-phenylpropanol 
• 100-46-9 benzylamine 
• 445298-95-3 (S,S)-N-methylpseudoephedrine α-bromo-α-methylacetate 

Downstream Products

• 120571-58-6 N-benzyl D-alanine methyl ester 

Relevant articles and documents

Dynamic resolution of α-bromo-α-alkyl esters using N-methyl pseudoephedrine as a chiral auxiliary: Asymmetric syntheses of α-amino acid derivatives

N-Methyl pseudoephedrine mediated dynamic resolution of α-bromo-α-alkyl esters in nucleophilic substitution reaction has been investigated. Best results are obtained when α-bromo-α-alkyl esters 1, 4 and 5 are allowed to equilibrate before the addition of nucleophile. This simple epimerization-substitution sequence provides a practical protocol for asymmetric syntheses of α-amino acid derivatives 2, 7 and 8 up to 98:2 enantiomeric ratio.