445413-41-2Relevant articles and documents
Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors
Ontoria, Jesus M.,Rydberg, Edwin H.,Di Marco, Stefania,Tomei, Licia,Attenni, Barbara,Malancona, Savina,Martin Hernando, José I.,Gennari, Nadia,Koch, Uwe,Narjes, Frank,Rowley, Michael,Summa, Vincenzo,Carroll, Steve S.,Olsen, David B.,De Francesco, Raffaele,Altamura, Sergio,Migliaccio, Giovanni,Carfì, Andrea
experimental part, p. 5217 - 5227 (2010/03/01)
The hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) plays a central role in virus replication. NS5B has no functional equivalent in mammalian cells and, as a consequence, is an attractive target for inhibition. Herein, we present 1H-benzo