445430-58-0 Usage
General Description
IKK Inhibitor III, also known as BMS-345541, is a potent and selective inhibitor of I-kappa-B Kinase (IKK), a protein complex that plays a crucial role in immunity processes and inflammatory response. By specifically inhibiting IKK, BMS-345541 can effectively block the activation of the nuclear factor-kappa B (NF-kB), a key regulator of cellular responses, including inflammation, cell growth, and survival. This chemical is often utilized in biological and medical research, especially in studies related to cancer, neuroscience, and immunology, given its ability to modulate cell signaling pathways and potentially suppress tumor growth.
Check Digit Verification of cas no
The CAS Registry Mumber 445430-58-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,5,4,3 and 0 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 445430-58:
(8*4)+(7*4)+(6*5)+(5*4)+(4*3)+(3*0)+(2*5)+(1*8)=140
140 % 10 = 0
So 445430-58-0 is a valid CAS Registry Number.
445430-58-0Relevant articles and documents
Imidazoquinoxaline compound for the treatment of melanoma
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Page/Page column 5, (2008/06/13)
The present invention concerns a (4(2′-aminoethyl)amino-1,8-dimethylimididazo(1,2-a)quinoxaline)-4,5-dihydro-1,8-dimethylimidazo(1,2-a)quinoxalin-4-one-2-carboxylic acid (BMS-345541) or an analog thereof for the treatment of melanoma cancer. This compound inhibits NFκB activity and expression, and induces apoptosis in melanoma cancer cells. The present invention also provides a method for assaying for the inhibition of melanoma cancer cell growth.
