4457-67-4Relevant articles and documents
Synthesis of new optically active 2-pyrrolidinones
Moutevelis-Minakakis, Panagiota,Papavassilopoulou, Eleni,Mavromoustakos, Thomas
, p. 50 - 73 (2013/03/14)
A new class of optically active 2-pyrrolidinones was synthesized, starting from S-pyroglutamic acid, a well known natural chiral synthon. The synthetic design followed led to the insertion of various substituents at positions 1 and 5 of the 2-pyrrolidinone ring, including the imidazole moiety. Some of them possess two or three stereogenic centers, the configuration of which was retained under the mild conditions used. The new compounds also carry an imidazole moiety, which, along with the 2-pyrrolidinone template, may prove pivotal to several biological processes.
1-substituted, 3-carboxylic acid piperidine derivatives
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, (2008/06/13)
The present invention relates to therapeutically active azaheterocyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating a central nervous system ailment related to the GABA uptake.
Anti-ferroelectric liquid crystal and liquid crystal display device
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, (2008/06/13)
A novel anti-ferroelectric liquid crystal of the formula (I), STR1 wherein: is an integer of 3 to 8, each of X and Y is independently a hydrogen atom or a fluorine atom, Z is --CF3, --CH3 or --C2 H5, q is 0 or 5, m is 0 or 1, n is an integer of 2 to 8, and C* is an asymmetric carbon, provided that when m is 0, q is 0 and n is an integer of 4 to 8 and that when m is 1, q is 5 and z is --CF3, and use of tile above liquid crystal as a liquid crystal display device.