446031-79-4 Usage
Description
1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester hydrochloride, also known as SSR 180711 Hydrochloride, is a chemical compound with a complex structure derived from diazabicyclic nonane and 4-bromophenyl ester. It is a partial agonist at the α7 nicotinic acetylcholine receptor (α7 nAChR) and has been found to have potential applications in the field of neuroscience and psychiatry due to its effects on cognitive function and neurotransmitter levels.
Uses
Used in Pharmaceutical Industry:
SSR 180711 Hydrochloride is used as a cognitive enhancer for improving episodic memory. It acts as a partial agonist at α7 nAChR, which is involved in various cognitive processes, including learning and memory. By enhancing the activity of this receptor, SSR 180711 Hydrochloride can potentially reverse deficits in episodic memory retention, making it a promising candidate for the treatment of memory-related disorders.
Used in Neuroscientific Research:
In the field of neuroscience, SSR 180711 Hydrochloride is used as a research tool to study the role of α7 nAChR in cognitive function and neurotransmitter regulation. Its ability to increase extracellular dopamine levels in the rat prefrontal cortex makes it a valuable compound for investigating the relationship between nAChR activation and dopamine release, which is crucial for understanding the underlying mechanisms of various neurological and psychiatric conditions.
Used in Antidepressant Development:
SSR 180711 Hydrochloride exhibits antidepressant-like properties, making it a potential candidate for the development of new antidepressant medications. Its mechanism of action involves the modulation of α7 nAChR, which has been implicated in the pathophysiology of depression. By targeting this receptor, SSR 180711 Hydrochloride may offer a novel approach to treating depression and other mood disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 446031-79-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,6,0,3 and 1 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 446031-79:
(8*4)+(7*4)+(6*6)+(5*0)+(4*3)+(3*1)+(2*7)+(1*9)=134
134 % 10 = 4
So 446031-79-4 is a valid CAS Registry Number.
446031-79-4Relevant articles and documents
ANTIPRURITIC AGENT
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Paragraph 0102; 0103; 0104; 0105; 0106; 0107, (2014/05/20)
An antipruritic which exerts an antipruritic effect based on a novel action mechanism and is effective for pruritus. The antipruritic contains as an effective ingredient a compound which activates a central type nicotinic acetylcholine receptor.
Pharmaceutical compositions for the treatment of disorders of the CNS and other disorders
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Page 18, (2010/01/31)
The present invention relates to a method of treating disorders of the central nervous system (CNS) and other disorders in a mammal, including a human, by administering to the mammal a CNS-penetrant α7 nicotinic receptor agonist. It also relates to pharmaceutical compositions containing a pharmaceutically acceptable carrier and a CNS-penetrant α7 nicotinic receptor agonist.
