4463-02-9

Basic information

• Product Name: 2,4,6-TRIHYDROXY-1,3-DIMETHYL BENZENE
• Synonyms: 2,4,6-Trihydroxy-m-xylene;2,4-Dimethyl-1,3,5-benzenetriol;2,4,6-TRIHYDROXY-1,3-DIMETHYL BENZENE;2,4,6-TRIHYDROXY-3-XYLENE;2,4-dimethylphloroglucinol;m-Xylene-2,4,6-triol;2,4-dimethylbenzene-1,3,5-triol
• CAS NO: 4463-02-9
• Molecular Formula: C₈H₁₀O₃
• Molecular Weight: 154.16
• EINECS: 224-725-9
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives
• Mol File: 4463-02-9.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 304.3 °C at 760 mmHg
• Flash Point: 151.9 °C
• Appearance: /
• Density: 1.314 g/cm³
• Vapor Pressure: 0.000489mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: 2,4,6-TRIHYDROXY-1,3-DIMETHYL BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-TRIHYDROXY-1,3-DIMETHYL BENZENE(4463-02-9)
• EPA Substance Registry System: 2,4,6-TRIHYDROXY-1,3-DIMETHYL BENZENE(4463-02-9)

Safety Data

• Hazardous Substances Data: 4463-02-9(Hazardous Substances Data)

Usage

Description

2,4,6-Trihydroxy-1,3-dimethyl benzene, also known as m-Xylene-2,4,6-triol, is an organic compound with a benzene ring structure featuring three hydroxyl groups at the 2, 4, and 6 positions and two methyl groups at the 1 and 3 positions. It is a versatile chemical intermediate with potential applications in various industries due to its unique molecular structure and functional groups.

Uses

Used in Pharmaceutical Industry:
2,4,6-Trihydroxy-1,3-dimethyl benzene is used as a reagent for the synthesis of flavanone derivatives, which exhibit anti-tumor activities. These flavanone derivatives have potential applications in the development of new cancer treatments, targeting various types of cancer cells and contributing to the advancement of oncology research.
Used in Chemical Synthesis:
Due to its unique structure and functional groups, 2,4,6-trihydroxy-1,3-dimethyl benzene can be used as a building block in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its versatility as a chemical intermediate makes it valuable in the development of new products and materials across different industries.

InChI:InChI=1/C8H10O3/c1-4-6(9)3-7(10)5(2)8(4)11/h3,9-11H,1-2H3

Upstream product

• 108-38-3 m-xylene 
• 632-92-8 2,4-dimethyl-1,3,5-trinitrobenzene 
• 97944-50-8 methyl 3-formyl-2,4,6-trihydroxy-5-methylbenzoate 
• 97761-87-0 3-Formyl-2,4,6-trihydroxy-benzoesaeure-methylester 
• 39828-33-6 2,4,6-Trihydroxy-3-methyl-benzoesaeure-methylester 
• 3147-39-5 methyl 2,4,6-trihydroxybenzoate 
• 108-73-6 3,5-dihydroxyphenol 
• 207924-64-9 1-tert-butyl-3,5-dimethyl-2,4,6-triaminobenzene 
• 7732-18-5 water 
• 859074-35-4 2,4,6-trihydroxy-3,5-dimethyl-benzoic acid methyl ester 
• 82-08-6 rottlerin 
• 74-88-4 methyl iodide 
• 94632-38-9 1,3-Dihydroxy-5-methoxy-2,4-dimethyl-benzol 
• 23848-22-8 2,6-Dimethylphloroglucin-1-monomethylether 

Downstream Products

• 95272-99-4 2-(3,4-dihydroxy-phenyl)-5,7-dihydroxy-6,8-dimethyl-chroman-4-one 
• 1402589-43-8 C₁₆H₁₆O₄ 
• 1402589-44-9 C₁₆H₁₅FO₄ 
• 1402589-45-0 C₁₆H₁₅ClO₄ 
• 1402589-46-1 C₁₇H₁₈O₅ 
• 1402589-48-3 C₁₆H₁₄Cl₂O₄ 
• 1402589-50-7 C₁₇H₁₈O₄ 
• 1402589-51-8 C₁₈H₂₀O₄ 
• 1402589-52-9 C₁₈H₁₉FO₄ 
• 1402589-53-0 C₁₈H₁₉ClO₄ 
• 1402589-55-2 C₁₉H₂₂O₅ 
• 1402589-56-3 C₁₈H₁₈Cl₂O₄ 
• 1402589-57-4 C₁₉H₂₂O₄ 
• 1390628-09-7 C₁₉H₂₀O₄ 

Relevant articles and documents

A Nouvel Route to Resorcinols

Hydroxylation of para-alkylated or 2,6-dialkylated phenols by hydrogen peroxide in SbF5-HF yields resorcinols, the electrophile reacting with the O-protonated substrate.

HALOGEN-SUBSTITUTED DIMETHYLCHALCONE DERIVATIVES AND PREPARATION METHOD THEREOF

The present invention relates to dimethylchalcone (DMC) derivatives substituted with halogen and a method for producing the same. A compound according to an embodiment of the present invention is represented by chemical formula I: [Chemical Formula I]. In Formula I, R1 and R2 are the same as or different from each other, R1, and R2 are each independently selected from the group consisting of hydrogen, methoxy, and methoxy. R3, and R4 are each independently hydrogen or halogen elements, and when R3 is hydrogen, R4 R4 is any one selected from the group consisting of halogen elements R3.

Discovery of Anti-TNBC Agents Targeting PTP1B: Total Synthesis, Structure-Activity Relationship, in Vitro and in Vivo Investigations of Jamunones

Twenty-three natural jamunone analogues along with a series of jamunone-based derivatives were synthesized and evaluated for their inhibitory effects against breast cancer (BC) MDA-MB-231 and MCF-7 cells. The preliminary structure-activity relationship revealed that the length of aliphatic side chain and free phenolic hydroxyl group at the scaffold played a vital role in anti-BC activities and the methyl group on chromanone affected the selectivity of molecules against MDA-MB-231 and MCF-7 cells. Among them, jamunone M (JM) was screened as the most effective anti-triple-negative breast cancer (anti-TNBC) candidate with a high selectivity against BC cells over normal human cells. Mechanistic investigations indicated that JM could induce mitochondria-mediated apoptosis and cause G0/G1 phase arrest in BC cells. Furthermore, JM significantly restrained tumor growth in MDA-MB-231 xenograft mice without apparent toxicity. Interestingly, JM could downregulate phosphatidylinositide 3-kinase (PI3K)/Akt pathway by suppressing protein-tyrosine phosphatase 1B (PTP1B) expression. These findings revealed the potential of JM as an appealing therapeutic drug candidate for TNBC.