4474-86-6 Usage
Description
N-Carbobenzyloxy-D-asparagine, also known as Nα-Cbz-D-asparagine, is a derivative of D-asparagine, an isomer of L-asparagine. It is an N-Cbz-protected form of D-asparagine, which is characterized by its white solid or powdery appearance. N-Carbobenzyloxy-D-asparagine plays a significant role in various applications due to its unique chemical properties and interactions.
Uses
1. Used in Pharmaceutical Industry:
N-Carbobenzyloxy-D-asparagine is used as a reagent for the synthesis of peptide antibiotics. Its unique structure allows it to be a crucial component in the development of new antibiotics, which can help combat drug-resistant bacteria and contribute to the advancement of medical treatments.
2. Used in Bacterial Culture:
N-Carbobenzyloxy-D-asparagine serves as a sole nitrogen source for the replication of certain bacteria, such as Saccharomyces cerevisiae. This application is essential in the field of microbiology and biotechnology, where the growth and maintenance of specific bacterial strains are required for research and industrial purposes.
3. Used in Enzyme Inhibition:
L-Asparagine, the isomer of D-asparagine, is a competitive inhibitor of staphylococcal L-asparaginase. N-Carbobenzyloxy-D-asparagine, due to its structural similarity, can also be utilized in the study and development of enzyme inhibitors, which have potential applications in the treatment of various diseases, including cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 4474-86-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,7 and 4 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4474-86:
(6*4)+(5*4)+(4*7)+(3*4)+(2*8)+(1*6)=106
106 % 10 = 6
So 4474-86-6 is a valid CAS Registry Number.
4474-86-6Relevant articles and documents
Synthesis of alanine and proline amino acids with amino or guanidinium substitution on the side chain
Zhang, Zhenyu,Aerschot, Arthur Van,Hendrix, Chris,Busson, Roger,David, Frank,Sandra, Pat,Herdewijn, Piet
, p. 2513 - 2522 (2007/10/03)
Competitive binding of peptides containing basic amino acids to disrupt or prevent the Tat-TAR interaction could result in diminished transcription as well as translation and hence constitutes an alternative way of controlling HIV replication. Therefore, we synthesized guanidinium and amino containing amino acids, based on a proline or an alanine scaffold. The introduction of the guanidinium moiety was best accomplished using 1H- pyrazole-1-carboxamidine hydrochloride, with Pmc used for its protection. The absence of racemization, maintained throughout the whole synthesis, was confirmed by chiral purity determination. These building blocks were smoothly incorporated into oligopeptides, which proved their suitability for use in a combinatorial approach for selecting TAR binding ligands. (C) 2000 Elsevier Science Ltd.
Optimization of Enantiocontrol for Carbon-Hydrogen Insertion with Chiral Dirhodium(II) Carboxamidates. Synthesis of Natural Dibenzylbutyrolactone Lignans from 3-Aryl-1-propyl Diazoacetates in High Optical Purity
Doyle, Michael P.,Protopopova, Marina N.,Zhou, Qi-Lin,Bode, Jeffrey W.,Simonsen, Stanley H.,Lynch, Vincent
, p. 6654 - 6655 (2007/10/03)
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Substituted urido amino and imino acids and esters
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, (2008/06/13)
Compounds of the formula STR1 wherein X is various imino or amino acids or esters are disclosed. These compounds possess angiotensin converting enzyme inhibition activity and depending upon the definition of X also possess enkephalinase inhibition activit
