447462-51-3

Basic information

• Product Name: (R)-4-oxo-2-(4-pyrrolidin-1-yl-phenyl)-butyric acid methyl ester
• Synonyms: (R)-4-oxo-2-(4-pyrrolidin-1-yl-phenyl)-butyric acid methyl ester
• CAS NO: 447462-51-3
• Molecular Weight: 261.321
• Mol File: 447462-51-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-4-oxo-2-(4-pyrrolidin-1-yl-phenyl)-butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-oxo-2-(4-pyrrolidin-1-yl-phenyl)-butyric acid methyl ester(447462-51-3)
• EPA Substance Registry System: (R)-4-oxo-2-(4-pyrrolidin-1-yl-phenyl)-butyric acid methyl ester(447462-51-3)

Safety Data

• Hazardous Substances Data: 447462-51-3(Hazardous Substances Data)

Upstream product

• 4096-21-3 N-phenylpyrrolidine 
• 5837-72-9 methyl (E)-4-oxo-2-butenoate 
• 7327-99-3 4-oxo-but-2-enoic acid methyl ester 

Downstream Products

• 95840-73-6 (2R)-2-phenylbutane-1,4-diol 
• 447463-03-8 1-{4-[3-(tert-butyl-dimethyl-silanyloxy)-1-(tert-butyl-dimethyl-silanyloxymethyl)-propyl]-phenyl}-pyrrolidine 
• 447462-40-0 [3-(tert-butyl-dimethyl-silanyloxy)-1-(tert-butyl-dimethyl-silanyloxymethyl)-propyl]-benzene 
• 447461-97-4 (R)-2-(4-pyrrolidin-1-yl-phenyl)-butan-1,4-diol 

Relevant articles and documents

Enantioselective transformation of alpha, beta-unsaturated aldehydes using chiral organic catalysts

Nonmetallic organic catalysts are provided that facilitate the enantioselective reaction of α,β-unsaturated aldehydes. The catalysts are chiral imidazolidinone compounds having the structure of formula (IIA) or (IIB) or are acid addition salts thereof, wherein, in one preferred embodiment, R1 is C1-C6 alkyl, R2 is tri(C1-C6 alkyl)-substituted methyl, R3 and R4 are hydrogen, and R5 is phenyl optionally substituted with 1 or 2 substituents selected from the group consisting of halo, hydroxyl, and C1-C6 alkyl. The chiral imidazolidinones are useful in catalyzing a wide variety of reactions, including cycloaddition reactions, Friedel-Crafts alkylation reactions, and Michael additions.

The enantioselective organocatalytic 1,4-addition of electron-rich benzenes to α,β-unsaturated aldehydes

The first enantioselective organocatalytic alkylation of electron-rich benzene rings with α,β-unsaturated aldehydes has been accomplished. The use of iminium catalysis has provided a new strategy for the enantioselective construction of benzylic stereogenicity, an important chiral synthon for natural product and medicinal agent synthesis. The (2S,5S)-5-benzyl-2-tert-butylimidazolidinone amine catalyst has been found to mediate the conjugate addition of a wide variety of substituted and unsubstituted anilines to unsaturated aldehydes. A diverse spectrum of aldehyde substrates can also be accommodated in this new organocatalytic transformation. While catalyst quantities of 10 mol % were generally employed in this study, successful alkylations conducted with catalyst loadings as low as 1 mol % are described. Copyright