4480-98-2

Basic information

• Product Name: 2-cycloheptylethanol
• Synonyms: Cycloheptaneethanol
• CAS NO: 4480-98-2
• Molecular Formula: C₉H₁₈O
• Molecular Weight: 142.2386
• Mol File: 4480-98-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 217.4°C at 760 mmHg
• Flash Point: 95.1°C
• Density: 0.893g/cm³
• Vapor Pressure: 0.0284mmHg at 25°C
• Refractive Index: 1.454
• CAS DataBase Reference: 2-cycloheptylethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cycloheptylethanol(4480-98-2)
• EPA Substance Registry System: 2-cycloheptylethanol(4480-98-2)

Safety Data

• Hazardous Substances Data: 4480-98-2(Hazardous Substances Data)

Usage

General Description

2-Cycloheptylethanol is a chemical compound with the molecular formula C9H18O. It is a colorless liquid with a fruity odor, and it is used as a solvent and in the production of perfumes and fragrances. It is also used as a flavoring agent in the food industry. 2-Cycloheptylethanol is considered to be relatively safe for use, with low toxicity and no known significant health hazards. However, it should still be handled with caution and in accordance with proper safety procedures.

Upstream product

• 14224-70-5 methyl 2-cycloheptylacetate 
• 4401-20-1 2-cycloheptylacetic acid 
• 502-42-1 cycloheptanone 
• 1903-23-7 ethyl cycloheptylideneacetate 
• 80246-70-4 ethyl cycloheptylacetate 

Downstream Products

• 4401-19-8 2-cycloheptylacetaldehyde 
• 21336-32-3 1-(2-hydroxyethyl)cyclohept-1-ene 
• 4448-83-3 α-(hydroxymethyl)methylenecycloheptane 
• 172606-13-2 2-(cyclohept-2-en-1-yl)ethanol 
• 146449-40-3 7-Chloro-2-[2-(4-methyl-cyclohexyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one 
• 146449-27-6 7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one 
• 118314-10-6 7-Amino-2-[2-(4-methyl-cyclohexyl)-ethyl]-6-nitro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one 
• 146449-15-2 7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one 
• 118313-98-7 5-[2-(4-Methyl-cyclohexyl)-ethyl]-[1,3,4]thiadiazol-2-ylamine 
• 22579-30-2 1-bromo-2-cycloheptylethane 

Relevant articles and documents

ASPARAGINE DERIVATIVES AND METHODS OF USE THEREOF

The present invention relates to compounds of formulas (A) and (I), pharmaceutically acceptable salts thereof, and solvates of any of them, pharmaceutical compositions comprising them, methods of preparation thereof, intermediate compounds useful for the preparation thereof, and methods of treatment or prophylaxis of diseases, in particular cancer, such as colorectal cancer, using these. (A) (I)

BIARYL PYRAZOLES AS NRF2 REGULATORS

The present invention relates to biaryl pyrazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.

Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction

The protein-protein interaction between the NMDA receptor and its intracellular scaffolding protein, PSD-95, is a potential target for treating ischemic brain diseases, neuropathic pain, and Alzheimer's disease. We have previously demonstrated that N-alkylated tetrapeptides are potent inhibitors of this interaction, and here, this template is exploited for the development of blood plasma-stable and cell-permeable inhibitors. Initially, we explored both the amino acid sequence of the tetrapeptide and the nature of the N-alkyl groups, which consolidated N-cyclohexylethyl-ETAV (1) as the most potent and selective compound. Next, the amide moieties of N-methylated ETAV were systematically replaced with thioamides, demonstrating that one of three amide bonds could be replaced without compromising the affinity. Subsequent optimization of the N-alkyl groups and evaluation of cell permeability led to identification of N-cyclohexylethyl-ETASV (54) as the most potent, plasma-stable and cell-permeable inhibitor, which is a promising tool in unraveling the therapeutic potential of the PSD-95/NMDA receptor interaction.