448920-97-6

Basic information

• Product Name: 6-(3-chloro-4-fluorobenzoyl)-1-Oxa-6-azaspiro[2.5]octane-2-carbonitrile
• Synonyms: 6-(3-chloro-4-fluorobenzoyl)-1-Oxa-6-azaspiro[2.5]octane-2-carbonitrile;6-(3-chloro-4-fluorobenzoyl)-2-cyano-1-oxa-6-azaspiro[2.5]octane
• CAS NO: 448920-97-6
• Molecular Weight: 294.713
• Mol File: 448920-97-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 6-(3-chloro-4-fluorobenzoyl)-1-Oxa-6-azaspiro[2.5]octane-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(3-chloro-4-fluorobenzoyl)-1-Oxa-6-azaspiro[2.5]octane-2-carbonitrile(448920-97-6)
• EPA Substance Registry System: 6-(3-chloro-4-fluorobenzoyl)-1-Oxa-6-azaspiro[2.5]octane-2-carbonitrile(448920-97-6)

Safety Data

• Hazardous Substances Data: 448920-97-6(Hazardous Substances Data)

Upstream product

• 107-14-2 chloroacetonitrile 
• 223632-64-2 1-[(3-chloro-4-fluorophenyl)carbonyl]piperidin-4-one 
• 403-16-7 3-chloro-4-fluorobenzoic acid 
• 65055-17-6 3-chloro-4-fluorobenzoyl chloride 

Downstream Products

• 635323-95-4 F₁₅₅₉₉ 
• 208110-64-9 (3-chloro-4-fluoro-phenyl)-(4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone 
• 448920-98-7 2-[1-[(3-chloro-4-fluorophenyl)carbonyl]-4-fluoropiperidin-4-yl]-2-hydroxyacetonitrile 

Relevant articles and documents

Novel Aryloxyethyl Derivatives of 1-(1-Benzoylpiperidin-4-yl)methanamine as the Extracellular Regulated Kinases 1/2 (ERK1/2) Phosphorylation-Preferring Serotonin 5-HT1A Receptor-Biased Agonists with Robust Antidepressant-like Activity

Novel 1-(1-benzoylpiperidin-4-yl)methanamine derivatives were designed as "biased agonists" of serotonin 5-HT1A receptors. The compounds were tested in signal transduction assays (ERK1/2 phosphorylation, cAMP inhibition, Ca2+ mobiliz

Synthesis method and intermediates of pyridin-2-yl-methylamine

The invention concerns a novel method for preparing pyridin-2-yl-methylamine derivatives by reducing amination of cyanohydrins.