448950-89-8 Usage
Description
7-Chloro-1-methyl-5-phenylis a chemical compound that serves as an impurity in Alprazolam (A575650) and is also identified as the major degradation product in Alprazolam tablets during their stability assay. It is characterized by its off-white solid appearance.
Uses
Used in Pharmaceutical Industry:
7-Chloro-1-methyl-5-phenylis used as an impurity in the production of Alprazolam, a medication primarily used to treat anxiety and panic disorders. Its presence is significant in the context of ensuring the quality and safety of Alprazolam tablets.
Additionally, as a degradation product in the stability assay of Alprazolam tablets, 7-Chloro-1-methyl-5-phenylplays a role in assessing the shelf life and stability of the medication, which is crucial for maintaining its efficacy and safety for patients.
In the field of pharmaceutical research and development, understanding the properties and behavior of compounds like 7-Chloro-1-methyl-5-phenylcan contribute to the improvement of drug formulations and the development of new medications with enhanced stability and effectiveness.
Check Digit Verification of cas no
The CAS Registry Mumber 448950-89-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,8,9,5 and 0 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 448950-89:
(8*4)+(7*4)+(6*8)+(5*9)+(4*5)+(3*0)+(2*8)+(1*9)=198
198 % 10 = 8
So 448950-89-8 is a valid CAS Registry Number.
448950-89-8Relevant articles and documents
Identification of Alprazolam and its degradation products using LC-MS-MS
Gonsalves, Alexandra Rocha,Pineiro, Marta,Martins, Jose Manuel,Barata, Pedro A.,Menezesc, Jose C.
experimental part, p. 128 - 141 (2010/08/07)
An efficient LC/MS/MS methodology for the analysis of Alprazolam API and Alprazolam tablets was developed. The analysis of the MS2 fragmentation profile, obtained from only one chromatographic assay, allows the identification of Alprazolam, its main degradation product, triazoaminoquinoleine (Imp G), the analysis of the MS3 spectra allows the identification of 5-chloro-[5-methyl-4H-1,2,4-triazol-4-yl]benzophenone (Imp C) and with SIM mode the 5-chloro-[2-(3-aminomethyl-5-methyl-1,2,4-triazol- 4-yl]benzophenone, opened-ring Alprazolam, proposed as precursor of triazoaminoquinoleine in basic and acid hydrolysis and only detected before by NMR analysis, was identified. With this method it is possible to study samples with only one chromatographic run, identifying unequivocally the impurities present, taking advantage of the MS-MS resource.