448964-37-2 Usage
Description
2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine is a tricyclic indan derivative characterized as a colorless oil. It is a chemical compound with a unique structure that holds potential in various applications due to its specific properties.
Uses
Used in Pharmaceutical Industry:
2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine is used as a potential therapeutic agent for sleep disorders. Its chemical structure and properties make it a promising candidate for the development of new treatments aimed at addressing various sleep-related conditions.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine serves as an intermediate for the production of Ramelteon (R110050), a drug used for the treatment of insomnia. Its role in the synthesis process is crucial for the development of this medication, highlighting its importance in the pharmaceutical sector.
Overall, 2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine is a versatile compound with applications in both the pharmaceutical industry and chemical synthesis, particularly in the development of treatments for sleep disorders and the production of specific medications.
Check Digit Verification of cas no
The CAS Registry Mumber 448964-37-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,8,9,6 and 4 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 448964-37:
(8*4)+(7*4)+(6*8)+(5*9)+(4*6)+(3*4)+(2*3)+(1*7)=202
202 % 10 = 2
So 448964-37-2 is a valid CAS Registry Number.
InChI:InChI=1/C13H17NO/c14-7-5-10-2-1-9-3-4-12-11(13(9)10)6-8-15-12/h3-4,10H,1-2,5-8,14H2
448964-37-2Relevant articles and documents
Preparation method of ramelteon
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Paragraph 0016-0022, (2020/06/16)
The invention belongs to the field of medicinal chemistry, and mainly relates to a (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)-1-ethylamine compound represented by a formula I. The method has the advantages that the operation is simple, the steps are reduced compared with the previous method, the route is shortened, and the used solvent is single in variety, convenient to recycle and high in yield, wherein the formula I is defined in the specification.
Preparation method of high-purity ramelteon
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Paragraph 0051; 0055, (2017/08/14)
The invention discloses a preparation method of high-purity ramelteon. The preparation method comprises the following steps: taking 1,2,6,7-tetrahydro-8H-indene[5,4-b]furan-8-ketone as a starting material; carrying out reduction and amino protection through wittig-horner reaction; carrying out amino deprotection under an acidic condition; carrying out hydrogenation reaction; then carrying out chiral resolution and acrylation reaction, thus obtaining the ramelteon. The ramelteon obtained through the invention is high in product purity and higher in yield; and formation of impurities is inhibited.
PROCESS OF MAKING RAMELTEON AND RELATED SUBSTANCES
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, (2009/01/24)
The present patent application provides a process for the preparation of compounds of the Formula (I) Wherein represents a single bond or a double bond. R represents ethyl, vinyl or ethynyl.