4497-03-4

Basic information

• Product Name: 3-MORPHOLIN-4-YL-N-PHENYL-PROPIONAMIDE HYDROCHLORIDE
• Synonyms: 3-MORPHOLIN-4-YL-N-PHENYL-PROPIONAMIDE HYDROCHLORIDE;3-Morpholino-N-phenyl-propanamide hydrochloride;3-(4-morpholinyl)-N-phenylpropanamide;3-(morpholin-4-yl)-N-phenylpropanamide
• CAS NO: 4497-03-4
• Molecular Formula: C₁₃H₁₈N₂O₂
• Molecular Weight: 234.29
• Mol File: 4497-03-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-MORPHOLIN-4-YL-N-PHENYL-PROPIONAMIDE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-MORPHOLIN-4-YL-N-PHENYL-PROPIONAMIDE HYDROCHLORIDE(4497-03-4)
• EPA Substance Registry System: 3-MORPHOLIN-4-YL-N-PHENYL-PROPIONAMIDE HYDROCHLORIDE(4497-03-4)

Safety Data

• Hazardous Substances Data: 4497-03-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H18N2O2.ClH/c16-13(14-12-4-2-1-3-5-12)6-7-15-8-10-17-11-9-15;/h1-5H,6-11H2,(H,14,16);1H

Upstream product

• 110-91-8 morpholine 
• 3460-04-6 3-chloro-N-phenylpropionamide 
• 74149-12-5 3?methylthio?N?phenylpropionamide 
• 62-53-3 aniline 
• 1020-16-2 3-morpholino-1-phenylpropan-1-one hydrochloride 

Relevant articles and documents

LiCl-promoted amination of β-methoxy amides (γ-lactones)

An efficient and mild method has been developed for the amination of β-methoxy amides (γ-lactones) including natural products michelolide, costunolide and parthenolide derivatives by using lithium chloride in good yields. This reaction is applicable to a wide range of substrates with good functional group tolerance. Mechanism studies show that the reactions undergo a LiCl promoted MeOH elimination from the substrates to form the corresponding α,β-unsaturated intermediates followed by the Michael addition of amines.

Novel method for preparing N-phenyl-3-morpholine propanamide

The invention relates to the technical field of fine chemical engineering, and discloses a novel method for preparing N-phenyl-3-morpholine propanamide. The method specifically comprises the followingstep that N-phenyl-3-methylthio propionamide, morpholin

Synthesis, toxicological and pharmacological assessment of morpholinooximes

The synthesis, pharmacology and toxicology of four morpholine derivatives from 1-(2-arylmorpholino)-3-phenyl-3-propanonoxime and the synthesis of two anilides are described. The structures of the synthesized derivatives were proved by IR, 1H NMR and occasionally with 13C NMR. The acute toxicity of the compounds in mice was determined. A comparative pharmacological study of the in vivo effect on the central nervous system was realised by the following screening tests: pentobarbital induced sleeping time, locomotor activity and behaviour despair test for antidepressive activity. The most active compound was 1-(2-phenylmorpholino)-3-phenyl-3- propanonoxime (2b) which showed low toxicity and antidepressive activity at a dose of 1/10 LD50.