449806-97-7

Basic information

• Product Name: Acetamide, N-[4-[[[(3S)-hexahydro-2-oxo-1H-azepin-3-yl](2-methylpropyl)amino]sulf onyl]phenyl]-
• CAS NO: 449806-97-7
• Molecular Formula: C18H27N3O4S
• Molecular Weight: 381.496
• Mol File: 449806-97-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[4-[[[(3S)-hexahydro-2-oxo-1H-azepin-3-yl](2-methylpropyl)amino]sulf onyl]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[4-[[[(3S)-hexahydro-2-oxo-1H-azepin-3-yl](2-methylpropyl)amino]sulf onyl]phenyl]-(449806-97-7)
• EPA Substance Registry System: Acetamide, N-[4-[[[(3S)-hexahydro-2-oxo-1H-azepin-3-yl](2-methylpropyl)amino]sulf onyl]phenyl]-(449806-97-7)

Safety Data

• Hazardous Substances Data: 449806-97-7(Hazardous Substances Data)

Upstream product

• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 359782-00-6 (3S)-3-isobutylamino-azepan-2-one 
• 21568-87-6 2-aminocaprolactam 

Downstream Products

• 449806-98-8 Nα-(4-Aminobenzenesulfonyl)-Nα-isobutyl-L-lysine Potassium Salt 
• 874339-75-0 (3S)-3-{[4-(acetyl-tert-butoxycarbonyl-amino)-benzenesulfonyl]-isobutyl-amino}-2-oxo-azepane-1-carboxylic acid tert-butyl ester 
• 652985-62-1 Nα-(4-aminobenzenesulfonyl)-Nα-isobutyl-L-lysine 
• 612548-08-0 (3S)-3-[(4-acetylamino-benzenesulfonyl)-isobutyl-amino]-2-oxo-azepane-1-carboxylic acid tert-butyl ester 
• 500221-64-7 {5-[(4-amino-benzenesulfonyl)-isobutyl-amino]-6-hydroxy-hexyl}-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 449806-88-6 Nα-(4-aminobenzenesulfonyl)-Nα-isobutyl-L-lysine methyl ester 
• 449806-99-9 (1S)-4-amino-N-(5-amino-1-hydroxymethyl-pentyl)-N-isobutyl-benzenesulfonamide 

Relevant articles and documents

Protease Inhibitors

The present invention provides HIV protease inhibitors of formulas I, IA, IB, Ib or II, or pharmaceutically acceptable salts thereof, wherein R2 may be, for example, 2-pyridyl-CH2—, 3-pyridyl-CH2—, 4-pyridyl-CH2—, a sulfonyl group as described in the formulas herein including benzenesulfonyl or thiophenesulfonyl groups, R2a—CO)—, R2a being selected from the group consisting of piperonyl, 2-pyranzinyl (unsubstituted or substituted with H, or an alkyl of 1 to 4 carbon atoms) or a picolylamine group as described herein, wherein R3 may be, for example, a phenyl group or diphenylmethyl group as described herein, and wherein Cx may be, for example, COOH, CONR5R6, CH2OH or CH2OR7.

Lysine sulfonamides as novel HIV-protease inhibitors: Nε-Acyl aromatic α-amino acids

A series of lysine sulfonamide analogues bearing Nε-acyl aromatic amino acids were synthesized using an efficient synthetic route. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type and multiple-protease inhibitor-resistant HIV viruses.

Lysine based compounds

The present invention provides lysine based compounds of the formula; and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein R1 may be, for example, (HO)2P(O)—, (NaO)2P(O)—, alkyl-CO— or cycloalkyl-CO—, wherein X may be, for example, F, Cl, and Br, and wherein R2 and R3 are as defined herein.