449811-63-6 Usage
Description
(2,4-Difluorophenoxy)acetic Acid Methyl Ester is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals. It is characterized by its fluorinated phenoxy group and ester functionality, which contribute to its reactivity and potential applications in the chemical and pharmaceutical industries.
Uses
Used in Pharmaceutical Industry:
(2,4-Difluorophenoxy)acetic Acid Methyl Ester is used as an intermediate in the synthesis of Pamapimod (P167500) for its role as a selective inhibitor of the α-isoform of p38 MAP kinase. This makes it a valuable compound in the development of targeted therapies for various diseases, including autoimmune and inflammatory conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 449811-63-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,9,8,1 and 1 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 449811-63:
(8*4)+(7*4)+(6*9)+(5*8)+(4*1)+(3*1)+(2*6)+(1*3)=176
176 % 10 = 6
So 449811-63-6 is a valid CAS Registry Number.
449811-63-6Relevant articles and documents
Development of radioiodinated pyrimidinopyridone derivatives as targeted imaging probes of activated p38α for single photon emission computed tomography
Hashimoto, Tomoyuki,Kondo, Naoya,Hirata, Masahiko,Temma, Takashi
, p. 1293 - 1304 (2021)
Objective: p38α, a member of the mitogen-activated protein kinase superfamily, is ubiquitously expressed in a variety of mammalian cells. Activated p38α induces inflammatory responses to external stimuli, suggesting that non-invasive detection of activate
