4501-35-3

Basic information

• Product Name: 1-CYCLOHEXYL-2-METHYL-BENZENE
• Synonyms: 1-CYCLOHEXYL-2-METHYL-BENZENE;2-Methyl-1-cyclohexylbenzene
• CAS NO: 4501-35-3
• Molecular Formula: C₁₃H₁₈
• Molecular Weight: 174.28202
• Mol File: 4501-35-3.mol
• Article Data: 42

Chemical Properties

• Boiling Point: 265.8°C at 760 mmHg
• Flash Point: 114.6°C
• Appearance: /
• Density: 0.932g/cm³
• Vapor Pressure: 0.0148mmHg at 25°C
• Refractive Index: 1.521
• CAS DataBase Reference: 1-CYCLOHEXYL-2-METHYL-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CYCLOHEXYL-2-METHYL-BENZENE(4501-35-3)
• EPA Substance Registry System: 1-CYCLOHEXYL-2-METHYL-BENZENE(4501-35-3)

Safety Data

• Hazardous Substances Data: 4501-35-3(Hazardous Substances Data)

Usage

General Description

1-Cyclohexyl-2-methylbenzene, also known as cumene, is a chemical compound with the formula C9H12. It is a colorless liquid with a sweet, gasoline-like odor and is commonly used as a solvent and in the production of phenol and acetone. Cumene is also a precursor to other chemicals, including synthetic camphor and diphenyl oxide. It is flammable and may cause skin and eye irritation upon contact. Additionally, exposure to cumene vapor may cause dizziness, headaches, and nausea. Therefore, proper handling and precautions should be taken when working with 1-cyclohexyl-2-methylbenzene to ensure safety in its use and storage.

InChI:InChI=1/C13H18/c1-11-7-5-6-10-13(11)12-8-3-2-4-9-12/h5-7,10,12H,2-4,8-9H2,1H3

Upstream product

• 22618-51-5 2'-methyl-2,3,4,5-tetrahydro-1,1'-biphenyl 
• 108-94-1 cyclohexanone 
• 108-88-3 toluene 
• 108-85-0 1-bromocyclohexane 
• 110-82-7 cyclohexane 
• 16419-60-6 2-Methylphenylboronic acid 
• 534-22-5 2-methylfuran 
• 695-12-5 vinylcyclohexane 
• 95-46-5 2-methylphenyl bromide 
• 446065-11-8 cyclohexyltrifluoro-λ⁴-borane potassium salt 
• 87100-15-0 cyclohexylboronic acid pinacol ester 
• 4441-56-9 cyclohexylboronic acid 
• 1976-04-1 2-bromo-N,N-dimethylbenzylamine 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 

Downstream Products

• 97023-48-8 2-cyclohexylbenzoic acid 
• 87-83-2 pentabromotoluene 

Relevant articles and documents

Cross-Coupling Reactions of Alkyl Halides with Aryl Grignard Reagents Using a Tetrachloroferrate with an Innocent Countercation

Bis(triphenylphosphoranylidene)ammonium tetrachloroferrate, (PPN)[FeCl4] (1), was evaluated as a catalyst for cross-coupling reactions. 1 exhibits high stability toward air and moisture and is an effective catalyst for the reaction of secondary alkyl halides with aryl Grignard reagents. The PPN cation is considered as an innocent counterpart to the iron center. We have developed an easy-to-handle iron catalyst for “ligand-free” cross-coupling reactions. (Figure presented.).

Enabling the Cross-Coupling of Tertiary Organoboron Nucleophiles through Radical-Mediated Alkyl Transfer

The construction of quaternary centers is a common challenge in the synthesis of complex materials and natural products. Current cross-coupling strategies that can be generalized for setting these centers are sparse and, when known, are typically predicated on the use of reactive organometallic reagents. To address this shortcoming a new, photoredox-Ni dual catalytic strategy for the cross-coupling of tertiary organoboron reagents with aryl halides is reported. In addition to details on the cross-coupling scope and limitations, full screening efforts and mechanistic experiments are communicated.

Sterically congested phosphonium borate acids as effective Br?nsted acid catalysts

Phosphonium borate acids [HPPh2(C6F5)][B(C6F5)4] (2), [HPMes2(C6F5)][B(C6F5)4] (3) and [HPMes(C6F5)2][B(C6F5)4] (4) were synthesized via heterolytic dihydrogen cleavage in the presence of triisopropylsilylium and characterized by spectroscopic and crystallographic methods. Br?nsted acid catalysis using compounds 2–4 proved to be efficient for a number of challenging reactions (namely ionic hydrogenation, hydroamination and hydroarylation), owing to the restrained nucleophilicity of the sterically hindered conjugate bases. Reactivity of compounds 2–4 suggests that their pKavalues are similar to that of diethyl oxonium acid.