450841-73-3

Basic information

• Product Name: 5-(3,5-difluoro-phenyl)-6-hydroxymethyl-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile
• CAS NO: 450841-73-3
• Molecular Weight: 276.242
• Mol File: 450841-73-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(3,5-difluoro-phenyl)-6-hydroxymethyl-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3,5-difluoro-phenyl)-6-hydroxymethyl-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile(450841-73-3)
• EPA Substance Registry System: 5-(3,5-difluoro-phenyl)-6-hydroxymethyl-1-methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile(450841-73-3)

Safety Data

• Hazardous Substances Data: 450841-73-3(Hazardous Substances Data)

Upstream product

• 4241-27-4 1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile 
• 450841-30-2 5-bromo-1,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile 

Relevant articles and documents

Pyridone-containing farnesyltransferase inhibitors: Synthesis and biological evaluation

Farnesyltransferase inhibitors (FTIs) have been developed as potential anti-cancer agents due to their efficacy in blocking malignant growth in a variety of murine models of human tumors. To that end, we have developed a series of pyridone farnesyltransferase inhibitors with potent in vitro and cellular activity. The synthesis, SAR and biological properties of these compounds will be discussed.