450844-51-6Relevant articles and documents
Synthesis of a novel farnesyl transferase inhibitor, ABT-100; Selective preparation of a stereogenic tertiary carbinol
Rozema, Michael J.,Kruger, Albert W.,Rohde, Bridget D.,Shelat, Bhadra,Bhagavatula, Lakshmi,Tien, James J.,Zhang, Weijiang,Henry, Rodger F.
, p. 4419 - 4425 (2005)
A stereoselective synthesis of ABT-100 1, a novel farnesyl transferase inhibitor, is described. The key step involves a stereoselective addition of the heterocyclic zinc reagent 10 to chiral α-keto ester 9 in >10:1 diastereoselectivity using menthol as th
Farnesyltransferase inhibitors
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, (2008/06/13)
Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.