451-80-9

Basic information

• Product Name: 2-FLUOROPHENETOLE
• Synonyms: Phenetole, o-fluoro-;2-FLUOROPHENETOLE;1-ETHOXY-2-FLUOROBENZENE;O-FLUOROPHENETOLE;Fluorophenetole1;2-Fluorophenetol;2-Fluorophenetole98%;2-Ethoxyfluorobenzene
• CAS NO: 451-80-9
• Molecular Formula: C₈H₉FO
• Molecular Weight: 140.15
• Product Categories: Phenetole;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds
• Mol File: 451-80-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: -16.7
• Boiling Point: 171-174 C
• Flash Point: 60.1 °C
• Appearance: /
• Density: 1.0874
• Vapor Pressure: 1.6mmHg at 25°C
• Refractive Index: 1.4932
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-FLUOROPHENETOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUOROPHENETOLE(451-80-9)
• EPA Substance Registry System: 2-FLUOROPHENETOLE(451-80-9)

Safety Data

• Hazard Codes: Xi,C
• Statements: 36/37/38-34
• Safety Statements: 26-36-45-36/37/39-27
• HazardClass: IRRITANT
• Hazardous Substances Data: 451-80-9(Hazardous Substances Data)

Usage

General Description

2-Fluorophenetole, also known as 1-fluoro-2-methoxybenzene, is a colorless liquid aromatic compound with the chemical formula C8H9FO. It is commonly used as an intermediate for the synthesis of pharmaceuticals and agrochemicals. 2-Fluorophenetole has a sweet, floral odor and is often used as a fragrance ingredient in perfumes and other personal care products. It is also used as a solvent and as a chemical intermediate in organic synthesis. The compound is considered to be a flammable liquid, and proper safety precautions should be taken when handling or storing it.

InChI:InChI=1/C8H9FO/c1-2-10-8-6-4-3-5-7(8)9/h3-6H,2H2,1H3

Upstream product

• 74-96-4 ethyl bromide 
• 367-12-4 2-fluorophenol 
• 103-73-1 Phenetole 
• 94-70-2 ortho-phenitidine 
• 109-63-7 boron trifluoride diethyl etherate 
• 64-17-5 ethanol 
• 113777-27-8 2-fluorophenyl trifluoromethanesulfonate 

Downstream Products

• 326-81-8 1-ethoxy-2-fluoro-4-nitrobenzene 
• 399-39-3 4-ethoxy-3-fluoroaniline 
• 1358580-28-5 (5-bromo-2-chloro-phenyl)-(4-ethoxy-3-fluoro-phenyl)methanone 
• 1191998-59-0 3-ethoxy-2-fluoro-phenol 
• 1358579-52-8 (1S,2S,3S,4R,5S)-5-[4-chloro-3-[dideuterio-(4-ethoxy-3-fluoro-phenyl)methyl]phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol 
• 1358581-88-0 [(1S,2S,3S,4R,5S)-2,3,4-tribenzyloxy-5-[4-chloro-3-[dideuterio-(4-ethoxy-3-fluorophenyl)methyl]phenyl]-6,8-dioxabicyclo[3.2.1]octan-1-yl]methanol 
• 1358581-87-9 [(3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[dideuterio-(4-ethoxy-3-fluorophenyl)methyl]phenyl]-2-(hydroxymethyl)-6-methoxy-tetrahydropyran-2-yl]methanol 
• 1358581-83-5 (2S,3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[dideuterio-(4-ethoxy-3-fluorophenyl)methyl]phenyl]-2-(hydroxymethyl)-6-methoxy-tetrahydropyran-2-carbaldehyde 
• 1358581-81-3 (2S,3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[dideuterio-(4-ethoxy-3-fluorophenyl)methyl]phenyl]-6-methoxy-tetrahydropyran-2-carbaldehyde 
• 1358581-77-7 [(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[dideuterio-(4-ethoxy-3-fluorophenyl)methyl]phenyl]-6-methoxy-tetrahydropyran-2-yl]methanol 
• 1358581-75-5 [[(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[4-chloro-3-[dideuterio-(4-ethoxy-3-fluorophenyl)methyl]phenyl]-6-methoxy-tetrahydropyran-2-yl]methoxy]tert-butyl-dimethyl-silane 
• 1358581-74-4 (2S,3R,4S,5S,6R)-6-[(tert-butyl(dimethyl)silyl)oxymethyl]-2-[4-chloro-3-[dideuterio-(4-ethoxy-3-fluoro-phenyl)methyl]phenyl]-2-methoxy-tetrahydropyran-3,4,5-triol 

Relevant articles and documents

Transition-Metal-Free C-C, C-O, and C-N Cross-Couplings Enabled by Light

Transition-metal-catalyzed cross-couplings to construct C-C, C-O, and C-N bonds have revolutionized chemical science. Despite great achievements, these metal catalysts also raise certain issues including their high cost, requirement of specialized ligands, sensitivity to air and moisture, and so-called "transition-metal-residue issue". Complementary strategy, which does not rely on the well-established oxidative addition, transmetalation, and reductive elimination mechanistic paradigm, would potentially eliminate all of these metal-related issues. Herein, we show that aryl triflates can be coupled with potassium aryl trifluoroborates, aliphatic alcohols, and nitriles without the assistance of metal catalysts empowered by photoenergy. Control experiments reveal that among all common aryl electrophiles only aryl triflates are competent in these couplings whereas aryl iodides and bromides cannot serve as the coupling partners. DFT calculation reveals that once converted to the aryl radical cation, aryl triflate would be more favorable to ipso substitution. Fluorescence spectroscopy and cyclic voltammetry investigations suggest that the interaction between excited acetone and aryl triflate is essential to these couplings. The results in this report are anticipated to provide new opportunities to perform cross-couplings.

Synthesis of aryl fluorides from potassium aryltrifluoroborates and selectfluor mediated by iron(III) chloride

The synthesis of fluorinated arenes by the iron-mediated fluorination of potassium aryltrifluoroborates with Selectfluor and potassium fluoride is described. The fluorination reaction uses commercially available reagents and without requiring the addition

Preparation process of fluorine substituted aromatic compound

A preparation process of a fluorine substituted aromatic compound comprising reacting an alkali metal or alkali earth metal salt of an aromatic compound having a hydroxy group with an organic fluorinating agent is disclosed. As a representative fluorinating agent, a bis-dialkylamino-difluoromethane compound, for example, 2,2′-difluoro-1,3-dimethylimidazolidine, is exemplified. According to the process, an industrially useful fluorinated aromatic compound, for example, a fluorobenzene, a fluorine substituted benzophenone, a fluorine substituted diarylsulfone can be prepared with ease in economy without specific equipment.