45158-94-9

Basic information

• Product Name: N-METHACRYLOYL-L-LYSINE
• Synonyms: N-METHACRYLOYL-L-LYSINE
• CAS NO: 45158-94-9
• Molecular Formula: C10H18N2O3
• Molecular Weight: 214.26
• Mol File: 45158-94-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 455.5 °C at 760 mmHg
• Flash Point: 229.3 °C
• Appearance: /
• Density: 1.109 g/cm³
• CAS DataBase Reference: N-METHACRYLOYL-L-LYSINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHACRYLOYL-L-LYSINE(45158-94-9)
• EPA Substance Registry System: N-METHACRYLOYL-L-LYSINE(45158-94-9)

Safety Data

• Hazardous Substances Data: 45158-94-9(Hazardous Substances Data)

Usage

General Description

N-Methacryloyl-L-lysine is a chemical compound that consists of a lysine amino acid with a methacryloyl group attached to it. It is commonly used as a cross-linking agent in the production of hydrogels for applications in tissue engineering and drug delivery systems. The methacryloyl group allows for the compound to participate in polymerization reactions, leading to the formation of stable gels. N-Methacryloyl-L-lysine is also employed in the synthesis of peptide-based materials for biomedical and biotechnological applications, where its biocompatibility and ability to mimic the natural environment of cells make it a valuable ingredient in the development of advanced biomaterials.

Upstream product

• 26124-78-7 (S)-α-lysine hydrochloride 
• 920-46-7 Methacryloyl chloride 
• 657-27-2 L-Lysine hydrochloride 
• 760-93-0 methacryloyl anhydride 

Relevant articles and documents

Skin care

PROBLEM TO BE SOLVED: To provide an external preparation for skin having both an excellent use feeling and a skin barrier recovery action without creakiness in use, and a tight feeling after use.SOLUTION: An external preparation for skin contains a co-polymer that essentially consists of: a constitutional unit derived from an acrylic monomer of which side chain includes an amino acid residue, a polyamine residue, or an amino alcohol residue; and a constitutional unit derived from an acrylic monomer including a constitutional unit derived from an acrylic monomer including a hydrophobic and specific branch structure.

Synthesis of pro-prodrugs l-lysine based for 5-aminosalicylic acid and 6-mercaptopurine colon specific release

The aim of this work is to design, prepare and characterize l-lysine based prodrugs capable of targeting 6-mercaptopurine to the colon, an anti-tumor and immunosuppressant drug, and 5-aminosalicylic acid (5-ASA), drug of choice for inflammatory bowel disease (IBD). More specifically, Nε-feruloyl-S-(6- purinyl)-l-lysine and Nε-acryloyl-S-(6-purinyl)-l-lysine were synthesized and then characterized by FT-IR, 1H-NMR and GC/MS spectroscopies. The ability of feruloyl derivative in inhibiting lipid peroxidation in rat liver microsomal membranes, induced in vitro by tert-butyl hydroperoxide as source of free radicals, was evaluated. Moreover, Nε-acryloyl-S-(6-purinyl)-l-lysine, polymerizable prodrug, was used to microspheres realization for 5-ASA release. These lasts, obtained by emulsion inverse technique, were characterized by light scattering and scanning electron microscopy (SEM) analysis. The microspheres equilibrium swelling degree was evaluated and showed good swelling behaviour in simulating colonic fluids. Results confirm the possibility that the application range of l-lysine prodrug can be extended to the treatment of intestinal diseases whose conventional therapy envisages medications with serious side effects that, thanks to this new strategy, can be minimized in an optimal way.