452-14-2 Usage
General Description
3-Fluoro-4-methoxyphenylacetic acid is a chemical compound with the formula C9H9FO3. It is a carboxylic acid derivative with a fluorine atom and a methoxy group attached to a phenyl ring. 3-FLUORO-4-METHOXYPHENYLACETIC ACID is often used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has also been studied for its potential biological and pharmacological properties. 3-Fluoro-4-methoxyphenylacetic acid is considered to be a valuable building block in organic chemistry due to its versatility and ability to be modified into various derivatives for different applications.
Check Digit Verification of cas no
The CAS Registry Mumber 452-14-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,5 and 2 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 452-14:
(5*4)+(4*5)+(3*2)+(2*1)+(1*4)=52
52 % 10 = 2
So 452-14-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H9FO3/c1-13-8-3-2-6(4-7(8)10)5-9(11)12/h2-4H,5H2,1H3,(H,11,12)/p-1
452-14-2Relevant articles and documents
Design and optimization of novel 4-(2-fluorophenoxy)quinoline derivatives bearing a hydrazone moiety as c-Met kinase inhibitors
Liao, Weike,Xu, Chen,Ji, Xiaohui,Hu, Gang,Ren, Lixiang,Liu, Yajing,Li, Ruijuan,Gong, Ping,Sun, Tiemin
, p. 508 - 518 (2015/01/09)
A series of 4-(2-fluorophenoxy)quinoline derivatives containing an acylhydrazone moiety were designed, synthesized and evaluated for their in vitro biological activities against c-Met kinase and five cancer cell lines (A549, H460, HT-29, MKN-45, and U87MG). Most compounds showed weak to excellent antiproliferative activity. The most promising analog, 40 (c-Met IC50 Combining double low line 1.86 nM), displayed 1.3-, 6.8-, 1.5-, 3.5-fold increase against HT-29, H460, A549 and U87MG cell lines, respectively, compared with Foretinib. An analysis of structure-activity relationships revealed that an acylhydrazone scaffold with an unsubstituted sp2 hybridized carbon adjacent to the 4-CF3 phenyl ring is favorable for antitumor activity.