452083-37-3

Basic information

• Product Name: 2-(2-bromomethyl-naphthalen-1-yl)-3,5-dimethoxy-phenol
• Synonyms: 2-(2-bromomethyl-naphthalen-1-yl)-3,5-dimethoxy-phenol
• CAS NO: 452083-37-3
• Molecular Weight: 373.246
• Mol File: 452083-37-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-bromomethyl-naphthalen-1-yl)-3,5-dimethoxy-phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-bromomethyl-naphthalen-1-yl)-3,5-dimethoxy-phenol(452083-37-3)
• EPA Substance Registry System: 2-(2-bromomethyl-naphthalen-1-yl)-3,5-dimethoxy-phenol(452083-37-3)

Safety Data

• Hazardous Substances Data: 452083-37-3(Hazardous Substances Data)

Upstream product

• 138435-70-8 1,3-dimethoxy-6H-benzo[b]naphto[1,2-d]pyranone 
• 140834-50-0 (rac)-2-hydroxymethyl-(2',4'-dimethoxy-6'-hydroxyphenyl)-naphthalene 

Downstream Products

• 452083-23-7 (rac)-1-(2'-acetoxy-4',6'-dimethoxyphenyl)-2-methylnaphthalene 
• 452083-22-6 (rac)-1-(2',4'-dimethoxy-6'-hydroxyphenyl)-2-methylnaphthalene 

Relevant articles and documents

Atropo-enantioselective total synthesis of knipholone and related antiplasmodial phenylanthraquinones

The "lactone concept" has been efficiently employed for the first atropo-enantioselective synthesis of knipholone and related natural phenylanthraquinones. Besides the regio- and stereoselective construction of the biaryl axis, another important step was the "synthetically late" introduction of the C-acetyl group, either by a Friedel-Crafts type acetylation or by an ortho-selective Fries rearrangement first tested on simplified model systems and subsequently applied to the highly atroposelective preparation of the natural products and of simplified analogs thereof for biotesting. The synthetic availability of these natural biaryls, their precursors, and their unnatural analogs permitted a broader investigation of the antiplasmodial activities of these interesting biaryls.