4522-35-4

Basic information

• Product Name: 3-Iodo-1H-pyrazole
• Synonyms: 3-Iodo-1H-pyrazole;3-Iodopyrazole;3-Iodo-1H-pyrazole≥ 98% (GC);3-Iodo-1H-Pyrazole(WX638030);1H-Pyrazole, 3-iodo-
• CAS NO: 4522-35-4
• Molecular Formula: C₃H₃IN₂
• Molecular Weight: 193.971
• Mol File: 4522-35-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 74-75°
• Boiling Point: 291.9 ℃ at 760 mmHg
• Flash Point: 130.3 ℃
• Appearance: /
• Density: 2.335 g/cm³
• Vapor Pressure: 0.00331mmHg at 25°C
• Refractive Index: 1.688
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 11.20±0.10(Predicted)
• Water Solubility: Insoluble in water.
• Sensitive: Light Sensitive
• CAS DataBase Reference: 3-Iodo-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Iodo-1H-pyrazole(4522-35-4)
• EPA Substance Registry System: 3-Iodo-1H-pyrazole(4522-35-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 4522-35-4(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white crystalline solid

Uses

3-Iodo-1H-pyrazole is used as pharmaceutical intermediate.

InChI:InChI=1/C3H3IN2/c4-3-1-2-5-6-3/h1-2H,(H,5,6)

Upstream product

• 1820-80-0 3-aminopyrazole 
• 632297-52-0 2-[(5-iodopyrazol-1-yl)methoxy]ethyl trimethylsilane 
• 917899-39-9 5-iodo-pyrazole-1-sulphonic acid dimethylamide 
• 141998-84-7 3-(tributylstannyl)-1H-pyrazole 

Downstream Products

• 92525-10-5 3-iodine-1-methyl-1H-pyrazole 
• 1007351-87-2 C₂₈H₃₈N₄O₄ 
• 1007351-64-5 C₂₅H₂₇N₃O₃ 
• 1007351-20-3 C₂₄H₂₅N₃O₂ 
• 877401-19-9 4-(3-iodo-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester 
• 1621525-07-2 3-(3-iodo-1H-pyrazol-1-yl)pyridine 
• 1621525-08-3 5-(3-iodo-1H-pyrazol-1-yl)-2-(trifluoromethyl)pyridine 
• 1621525-09-4 3-(3-iodo-1H-pyrazol-1-yl)-5-(trifluoromethyl)pyridine 
• 1621525-10-7 5-(3-iodo-1H-pyrazol-1-yl)nicotinonitrile 
• 1621525-11-8 3-fluoro-4-(3-iodo-1H-pyrazol-1-yl)pyridine 
• 1621525-12-9 4-(3-iodo-1H-pyrazol-1-yl)-2-methylpyridine 
• 1621525-13-0 4-(3-iodo-1H-pyrazol-1-yl)-2-isopropoxypyridine 
• 1621525-14-1 4-(3-iodo-1H-pyrazol-1-yl)-N,N-dimethylpyridin-2-amine 
• 1621525-15-2 methyl 4-(3-iodo-1H-pyrazol-1-yl)picolinate 

Relevant articles and documents

PYRAZOLE DERIVATIVES

Provided herein are compounds of the formula I: as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment or prevention of mGluR5 mediated disorders, such as acute and/or chronic neurological disorders, cognitive disorders and memory deficits, as well as acute and chronic pain.

TYROSINE KINASE INHIBITORS

The present invention relates to pyridinyloxy- and pyrimidinyloxyindole derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

PYRAZOLE-SUBSTITUTED AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS

Compounds of formula (1) are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.