452967-40-7

Basic information

• Product Name: 6-Bromo-2-(4-methoxyphenyl)imidazo[1,2-a]pyridine
• Synonyms: 6-Bromo-2-(4-methoxyphenyl)imidazo[1,2-a]pyridine;IMidazo[1,2-a]pyridine,6-broMo-2-(4-Methoxyphenyl)-
• CAS NO: 452967-40-7
• Molecular Formula: C14H11BrN2O
• Molecular Weight: 303.15
• Mol File: 452967-40-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.47
• Refractive Index: 1.649
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-Bromo-2-(4-methoxyphenyl)imidazo[1,2-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-2-(4-methoxyphenyl)imidazo[1,2-a]pyridine(452967-40-7)
• EPA Substance Registry System: 6-Bromo-2-(4-methoxyphenyl)imidazo[1,2-a]pyridine(452967-40-7)

Safety Data

• Hazardous Substances Data: 452967-40-7(Hazardous Substances Data)

Usage

General Description

6-Bromo-2-(4-methoxyphenyl)imidazo[1,2-a]pyridine is a chemical compound with the molecular formula C14H11BrN2O. It is a heterocyclic organic compound that belongs to the class of imidazo[1,2-a]pyridines. This chemical contains a bromine atom, a methoxy group, and a phenyl ring, which gives it a unique structure. It has potential applications in pharmaceutical research and drug development, particularly in the synthesis of new bioactive compounds. Its specific properties and potential uses are still being studied and explored by researchers in the field of chemistry and pharmacology.

InChI:InChI=1/C14H11BrN2O/c1-18-12-5-2-10(3-6-12)13-9-17-8-11(15)4-7-14(17)16-13/h2-9H,1H3

Upstream product

• 1072-97-5 5-bromo-2-pyridylamine 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 

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The vanadium-catalyzed oxidative coupling of substituted 2-arylimidiazo[1,2-a]pyridines to N-methylmorpholine oxide, which acts as both a coupling partner and an oxidant, has been achieved. This reaction was applied to various substituted imidiazo[1,2-a]pyridine and indole substrates, resulting in yields as high as 90%. Mechanistic investigations indicate that the reaction may proceed via a Mannich-type process. This work demonstrates how oxidative aminomethylation can be used as a useful method to introduce tertiary amines into heterocycles, thus providing an alternative method for conventional Mannich-type reactions.