453-35-0

Basic information

• Product Name: 1,1,1-TRIFLUORO-3-NITROPROPAN-2-OL
• Synonyms: 3,3,3-TRIFLUORO-2-HYDROXY-1-NITROPROPANE;1,1,1-TRIFLUORO-3-NITROPROPAN-2-OL;3,3,3-TRIFLUORO-2-HYDROXY-1-NITROPROPANE, 97% MIN.;2-Hydroxy-1-nitro-3,3,3-trifluoropropane;3-Nitro-1,1,1-trifluoropropan-2-ol
• CAS NO: 453-35-0
• Molecular Formula: C3H4F3NO3
• Molecular Weight: 159.06
• Mol File: 453-35-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 60 °C
• Flash Point: 88.7°C
• Appearance: /
• Density: 1.513g/cm³
• Vapor Pressure: 0.02mmHg at 25°C
• Refractive Index: 1.372
• CAS DataBase Reference: 1,1,1-TRIFLUORO-3-NITROPROPAN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,1-TRIFLUORO-3-NITROPROPAN-2-OL(453-35-0)
• EPA Substance Registry System: 1,1,1-TRIFLUORO-3-NITROPROPAN-2-OL(453-35-0)

Safety Data

• Hazardous Substances Data: 453-35-0(Hazardous Substances Data)

Usage

General Description

1,1,1-Trifluoro-3-nitropropan-2-ol is a chemical compound with the formula CF3CH(OH)CH(NO2)CH3. It is a colorless liquid with a strong odor. 1,1,1-TRIFLUORO-3-NITROPROPAN-2-OL is primarily used as an intermediate in the synthesis of pharmaceuticals, agricultural chemicals, and other organic compounds. It is also used as a solvent in various chemical reactions. 1,1,1-Trifluoro-3-nitropropan-2-ol is considered to be toxic and should be handled with caution. It is important to follow proper safety procedures when handling this chemical, including wearing protective equipment and working in a well-ventilated area.

InChI:InChI=1/C3H4F3NO3/c4-3(5,6)2(8)1-7(9)10/h2,8H,1H2

Upstream product

• 75-52-5 nitromethane 
• 421-53-4 2,2,2-trifluoro-1,1-ethanediol 
• 461-24-5 1,1,1-trifluoroethyl ethyl ether 
• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 112091-98-2 1,1,1-trifluoro-2-diazo-3-nitropropane 
• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 

Downstream Products

• 371-96-0 (E)-3,3,3-trifluoro-1-nitroprop-1-ene 
• 431-38-9 3-amino-1,1,1-trifluoropropan-2-ol 

Relevant articles and documents

Highly regio- and stereoselective 1,3-dipolar cycloaddition of stabilised azomethine ylides to 3,3,3-trihalogeno-1-nitropropenes: Synthesis of trihalomethylated spiroindenepyrroli(zi)dines

Reactions of (E)-3,3,3-trihalogeno-1-nitropropenes with stabilised azomethine ylides derived from ninhydrin and indenoquinoxalinones on the one hand, and sarcosine and proline on the other, proceed regio- and diastereoselectively to give a number of trihalomethylated spiroindenepyrrolidines and spiroindenepyrrolizidines in good yields.

6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES

The present invention relates to compounds of the formula (I) or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R4 are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.

The asymmetric Friedel-Crafts reaction of indoles with fluoroalkylated nitroalkenes catalyzed by chiral phosphoric acid

The enantioselective Friedel-Crafts fluoroalkylation of indoles with fluoroalkylated nitroalkenes, catalyzed by chiral phosphoric acid is described. The regioselectivity of fluoroalkylated nitroalkenes is a problem worth discussing, and it was found that the carbon atom adjacent to the fluoroalkyl group is more reactive than that adjacent to NO2 group.