4530-21-6

Basic information

• Product Name: enniatin A1
• Synonyms: enniatin A1;2-(N-Methyl-L-valine)enniatin A;Cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl];(3S,6R,9S,12R,15S,18R)-3,9-bis[(2S)-butan-2-yl]-4,10,16-trimethyl-6,12,15,18-tetra(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
• CAS NO: 4530-21-6
• Molecular Formula: C35H61N3O9
• Molecular Weight: 667.879
• Mol File: 4530-21-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 116-117 °C
• Boiling Point: 840.5±65.0 °C(Predicted)
• Appearance: /
• Density: 1.027±0.06 g/cm3(Predicted)
• Storage Temp.: ?20°C
• Solubility: DMSO: soluble10mg/mL
• PKA: -1.44±0.70(Predicted)
• CAS DataBase Reference: enniatin A1(CAS DataBase Reference)
• NIST Chemistry Reference: enniatin A1(4530-21-6)
• EPA Substance Registry System: enniatin A1(4530-21-6)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25
• Safety Statements: 45
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1(a)
• PackingGroup: I
• Hazardous Substances Data: 4530-21-6(Hazardous Substances Data)

Usage

Description

Enniatin A1 is a mycotoxin and a member of the enniatin complex, which is a family of depsipeptide ionophores produced by several Fusarium species. It is derived from the formal cyclocondensation of specific amino acid units and has the ability to cross the blood-brain barrier, causing negative CNS effects. Enniatin A1 has been the subject of increased research due to its effects on acyl-CoA cholesterol transferase, transporters, and the selectivity of its antitumor action.

Uses

Used in Pharmaceutical Industry:
Enniatin A1 is used as a pharmaceutical agent for its antitumor properties. It has been found to have selective action against certain types of cancer, making it a potential candidate for cancer treatment. enniatin A1 modulates various cellular processes, including acyl-CoA cholesterol transferase and transporter functions, which contribute to its antitumor effects.
Used in Research Applications:
Enniatin A1 is used as a research tool to study the mechanisms of action and potential applications in cancer therapy. Its effects on acyl-CoA cholesterol transferase, transporters, and the selectivity of its antitumor action provide valuable insights into the development of novel cancer treatments.
Used in Environmental and Health Studies:
Enniatin A1 is used in studies related to mold, moisture damage, and asthma development. As a secondary metabolite of microbes, it is associated with these environmental and health issues, and understanding its role can help in developing strategies to mitigate their impact.
Used in Toxicology:
Enniatin A1 is used in toxicology research to understand its effects on the central nervous system (CNS) and its potential as a mycotoxin. This knowledge can contribute to the development of methods to detect and prevent exposure to enniatin A1 and other similar compounds.