4539-70-2

Basic information

• Product Name: Lecithindistearoyl
• Synonyms: Lecithindistearoyl;StearoylLecithin;1,2-distearoyllecithin;2,3-di(octadecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate;2,3-distearoyloxypropyl 2-(trimethylammonio)ethyl phosphate
• CAS NO: 4539-70-2
• Molecular Formula: C₄₄H₈₈NO₈P
• Molecular Weight: 790.145181
• Mol File: 4539-70-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Lecithindistearoyl(CAS DataBase Reference)
• NIST Chemistry Reference: Lecithindistearoyl(4539-70-2)
• EPA Substance Registry System: Lecithindistearoyl(4539-70-2)

Safety Data

• Hazardous Substances Data: 4539-70-2(Hazardous Substances Data)

Usage

General Description

Lecithindistearoyl is a compound that belongs to the class of phospholipids, specifically a type of lecithin that contains two stearic acid molecules. Lecithindistearoyl is commonly used in the food industry as an emulsifier and stabilizer, helping to mix ingredients that would otherwise separate, such as oil and water. Lecithindistearoyl is also found in various cosmetic and personal care products, where it acts as a surfactant to enhance the texture and consistency of the product. While generally considered safe for consumption and topical use, individuals with allergies or sensitivities to lecithin or stearic acid should exercise caution when using products containing lecithindistearoyl.

InChI:InChI=1/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3

Upstream product

• 57-11-4 stearic acid 
• 111-63-7 vinyl stearate 
• 34688-34-1 glycerolcholine phosphate 
• 2258-41-5 α-Linoloyl-β-stearoyl-glycerin 
• 66152-20-3 2-(1,2-Distearoyl-rac-3-glyceryl)-1,3,2-dioxaphospholan 
• 24529-89-3 3-hydroxypropane-1,2-diyl (9Z,9’Z,12Z,12’Z)-bis(octadeca-9,12-dienoate) 
• 51063-97-9 DL-α,β-distearin 
• 59573-98-7 Octadecanoic acid 1-octadecanoyloxymethyl-2-(2-oxo-2λ⁵-[1,3,2]dioxaphospholan-2-yloxy)-ethyl ester 
• 75-50-3 trimethylamine 
• 18498-22-1 DL-1.2-Distearoyl-glycerin-phosphorsaeure-⁽³⁾-mono-2-brom-aethylester 
• 4167-02-6 2-bromoethylphosphoric acid dichloride 
• 6542-05-8 1,2-Dilinoleoyl-sn-glycerol-3-phosphorylcholine 
• 107437-06-9 α-<α'-Linoleoyl-β-stearoyl>-phosphatidylcholin 
• 55357-38-5 choline tosylate 

Downstream Products

• 17364-19-1 1-stearoyl-sn-glycero-3-phosphocholine 
• 18892-74-5 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine 
• 6753-53-3 1-octadecanoyl-2-[cis-9,12]-octadecadienoyl-glycero-3-phosphocholine 
• 67-48-1 choline chloride 

Relevant articles and documents

Method for preparing difatty acyl phosphatidylcholine by solid-phase reaction

The invention relates to a method for preparing difatty acyl phosphatidylcholine by a solid-phase reaction. Glycerol phosphatidylcholine is subjected to wet-process loading by using a high-activity solid adsorbent, and then a condensation reaction is carried out on the glycerol phosphatidylcholine with fatty acid to obtain the difatty acyl phosphatidylcholine. The method comprises the following steps: dissolving glyceryl phosphatidylcholine in an organic solvent, adding a high-activity solid adsorbent, carrying out adsorbing dispersion while stirring, removing the organic solvent by vacuum evaporation, and carrying out vacuum drying on the obtained solid-phase loaded mixed material; dissolving fatty acid in an organic solvent, adding a condensation coupling agent, carrying out heating reflux to prepare active ester of fatty acid, adding the solid-phase loaded glyceryl phosphatidylcholine, and continuing reflux to prepare a difatty acyl phosphatidylcholine crude product; and carrying out filtering to recover the high-activity solid adsorbent, desolventizing mother liquor, pulping a crude product by using an organic solvent, and carrying out recrystallizing to obtain the high-puritydifatty acyl phosphatidylcholine. According to the method, the reaction yield reaches 65% or above, the product purity reaches 99% or above, the process is simple, the production period is short, andindustrial production is easy to achieve.

Process for the production of phospholipids

A new enzymatic process for preparing 1,2-diacylated phospholipids using an enzyme preparation possessing phospholipase activity towards acylation at the sn-1 and sn-2 sites in a microaqueous reaction system. More particularly, the 1,2-diacyl-phospholipids produced according to the esterification/transesterification process are obtainable in high yield and purity and carry identical desired carboxylic acid, preferably fatty acid, acyl groups at the sn-1 and sn-2 positions. The process involves esterification/transesterification (acylation) of a glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of the above mentioned appropriate enzyme preparation. The process of the invention further relates to a process for the production of 1-acyl-2-lyso-glycerophospholipid, preferably 2-lyso-PC by reacting glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of a sn-1 specific phospholipase (PLA1 or PLA1,2) and a solvent, in a microaqueous medium.

Composition and method for treatment of disseminated fungal infections in mammals

A method is disclosed for treatment of disseminated fungal infection in a mammal comprising the administration of a fungicidally effective amount of Amphotericin B encapsulated in a substantially sterol-free liposome to the infected mammal. Also provided is an agent for treatment of disseminated fungal infection in a mammal comprising Amphotericin B encapsulated in a liposome which consists essentially of lipids other than sterols.