454217-40-4Relevant articles and documents
Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity
Block, Michael H.,Boyer, Scott,Brailsford, Wayne,Brittain, David R.,Carroll, Debra,Chapman, Steve,Clarke, David S.,Donald, Craig S.,Foote, Kevin M.,Godfrey, Linda,Ladner, Anthony,Marsham, Peter R.,Masters, David J.,Mee, Christine D.,O'Donovan, Michael R.,Pease, J. Elizabeth,Pickup, Adrian G.,Rayner, John W.,Roberts, Andrew,Schofield, Paul,Suleman, Abid,Turnbull, Andrew V.
, p. 3509 - 3523 (2007/10/03)
The hypothesis that antagonists of the neuropeptide Y5 receptor would provide safe and effective appetite suppressants for the treatment of obesity has prompted vigorous research to identify suitable compounds. We discovered a series of acylated aminocarb