45506-41-0

Basic information

• Product Name: 2-PIPERIDINOL
• Synonyms: 2-PIPERIDINOL;2-HYDROXYPIPERIDINE;piperidin-2-ol;Piperidin-2-ol hydrochloride
• CAS NO: 45506-41-0
• Molecular Formula: C₅H₁₁NO
• Molecular Weight: 101.15
• Product Categories: Piperidine
• Mol File: 45506-41-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 180.447 °C at 760 mmHg
• Flash Point: 93.703 °C
• Appearance: /
• Density: 1.017 g/cm³
• CAS DataBase Reference: 2-PIPERIDINOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PIPERIDINOL(45506-41-0)
• EPA Substance Registry System: 2-PIPERIDINOL(45506-41-0)

Safety Data

• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36:Wear suitable prot
• Hazardous Substances Data: 45506-41-0(Hazardous Substances Data)

Usage

General Description

2-Piperidinol is a chemical compound with the molecular formula C5H11NO. It is a white to off-white solid at room temperature and has a characteristic amine-like odor. 2-Piperidinol is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a solvent and a reagent in laboratory research. The compound has been studied for its potential as a therapeutic agent in the treatment of neurological and psychiatric disorders, as well as for its potential use as a precursor in the production of various drugs and chemicals. However, 2-Piperidinol is also known to be toxic and can cause irritation to the skin, eyes, and respiratory system, so proper precautions should be taken when handling and using this substance.

InChI:InChI=1/C5H11NO.ClH/c7-5-3-1-2-4-6-5;/h5-7H,1-4H2;1H

Synthetic route

Cyclopentanone oxime (1192-28-5) → 2-hydroxy piperidine (45506-41-0)

Conditions	Yield
Multi-step reaction with 2 steps 1: thionyl chloride / dichloromethane / 6 h / 30 - 35 °C 2: cobalt(II) acetate; sodium tetrahydroborate / water / 12 h / 15 - 25 °C View Scheme

piperidin-2-one (675-20-7) → 2-hydroxy piperidine (45506-41-0)

Conditions	Yield
With sodium tetrahydroborate; cobalt(II) acetate In water at 15 - 25℃; for 12h;

cyclopentanone (120-92-3) → 2-hydroxy piperidine (45506-41-0)

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium hydroxide; hydroxylamine hydrochloride / water / 3.5 h / 20 - 30 °C 2: thionyl chloride / dichloromethane / 6 h / 30 - 35 °C 3: cobalt(II) acetate; sodium tetrahydroborate / water / 12 h / 15 - 25 °C View Scheme

2-hydroxy piperidine (45506-41-0) → 2-piperideine (37497-65-7)

Conditions	Yield
With ammonium chloride at 15 - 25℃; for 5h;	91.19%

2-hydroxy piperidine (45506-41-0) → (2-oxopiperidine-1-yl)chlorobenzene

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydrogensulfite; sulfuric acid / 230 °C / 20252 Torr 2: sulfuric acid; iron(III) chloride / water View Scheme

2-hydroxy piperidine (45506-41-0) → ethyl 7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazole[3,4-c]pyridine-3-carboxylate

Conditions	Yield
Multi-step reaction with 3 steps 1: sodium hydrogensulfite; sulfuric acid / 230 °C / 20252 Torr 2: sulfuric acid; iron(III) chloride / water 3: sodium hydroxide / butan-1-ol / 120 °C View Scheme

2-hydroxy piperidine (45506-41-0) → 7-oxo-6-[4-(2-oxopiperidine-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazole[3,4-c]pyridine-3-carboxylic acid

Conditions	Yield
Multi-step reaction with 4 steps 1: sodium hydrogensulfite; sulfuric acid / 230 °C / 20252 Torr 2: sulfuric acid; iron(III) chloride / water 3: sodium hydroxide / butan-1-ol / 120 °C 4: sodium hydroxide / water; methanol / Reflux View Scheme

Upstream product

• 120-92-3 cyclopentanone 
• 675-20-7 piperidin-2-one 
• 1192-28-5 Cyclopentanone oxime 

Downstream Products

• 27471-37-0 (2-oxopiperidine-1-yl)chlorobenzene 
• 2402-77-9 2,3-dichloro-pyridine 

Relevant articles and documents

Synthetic method 2-3 -dichloropyridine (by machine translation)

The invention provides 2-3 -dichloropyridine synthesis method which comprises the following steps: reacting cyclopentanone with hydroxylamine hydrochloride to obtain compound A; compound A under the action of ammonium chloride to obtain compound C; compound C under the action of ammonium chloride to obtain compound D; compound E reacts with chlorine to obtain compound E; compound E and tert-butylphosphinic acid ester are reacted to obtain 2, 3 - dichloropyridines. The method has the advantages of simple operation steps, cheap and easily available reaction raw materials, 68.88%% of total molar yield, 2 or more purity 3 - 98.0% -dichloropyridine, and good product quality, and is suitable for industrial production. (by machine translation)