45533-49-1

Basic information

• Product Name: 2-(propan-2-yl)-4,5-dihydro-1,3-thiazole
• Synonyms: Thiazole, 4,5-dihydro-2-(1-methylethyl)-
• CAS NO: 45533-49-1
• Molecular Formula: C₆H₁₁NS
• Molecular Weight: 129.2232
• Mol File: 45533-49-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 171.5°C at 760 mmHg
• Flash Point: 57.5°C
• Density: 1.09g/cm³
• Vapor Pressure: 1.86mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: 2-(propan-2-yl)-4,5-dihydro-1,3-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(propan-2-yl)-4,5-dihydro-1,3-thiazole(45533-49-1)
• EPA Substance Registry System: 2-(propan-2-yl)-4,5-dihydro-1,3-thiazole(45533-49-1)

Safety Data

• Hazardous Substances Data: 45533-49-1(Hazardous Substances Data)

Upstream product

• 6282-73-1 N-(2-hydroxyethyl)isobutyramide 
• 78-82-0 Isobutyronitrile 
• 60-23-1 Cysteamine 
• 547-63-7 Methyl isobutyrate 
• 156-57-0 2-mercaptoethylamine hydrochloride 
• 24050-11-1 2-isopropyl-1,3-thiazolidine 
• 81563-10-2 (Z)-3-(2-Amino-ethylsulfanyl)-4-methyl-pent-2-enenitrile 

Downstream Products

• 55089-28-6 2-(1,1-dimethyl-2-phenyl-ethyl)-4,5-dihydro-thiazole 
• 13146-74-2 8a-Isopropyl-5,7-dioxo-2,3,5,6,7,8,8a-heptahydro-thiazolo<3,2-a>-s-triazin 

Relevant articles and documents

Microwave-Assisted Synthesis of 2-Substituted 2-Thiazolines and 5,6-Dihydro-4 H -1,3-thiazines

An efficient and general method for the synthesis of 2-substituted thiazolines and 5,6-dihydro-4 H -1,3-thiazines is developed via microwave-assisted ring closure of ω-thioamidoalcohols promoted by ethyl polyphosphate (PPE). The cyclization reaction involves an S N 2-type mechanism and features the advantages of very short reaction times, high yields and a predictable stereochemical outcome. The acyclic precursors are prepared in high overall yields by an improved diacylation-thionation-saponification sequence from commercially available ω-amino alcohols. The whole process is metal-free and operationally simple.

Novel synthesis of 2-thiazolines

The synthesis of a series of 2-thiazolines was carried out under mild conditions from the corresponding thiazolidines, by a Ru-catalyzed/TBHP oxidation reaction conditions. The reaction was chemoselective towards the amine-imine oxidation and was also regioselective, affording the unsaturation at the 2-position of the heterocycle, even with thiazolidine substrates bearing ester groups at the 4-position. (C) 2000 Elsevier Science Ltd.

Research on radioprotective agents: Δ-2 Thiazolines and homologous derivatives

Compounds derived from Δ-2 thiazoline, Δ-2 thiazolinium iodoalkylate and 4,5-dihydro-1,3 thiazine have been prepared and evaluated as potential antiradiation agents in mice. They generally have a low toxicity and significant radioprotective activity.