4558-87-6

Basic information

• Product Name: 2,5-dimethylpiperidin-4-one
• Synonyms: 4-piperidinone, 2,5-dimethyl-
• CAS NO: 4558-87-6
• Molecular Formula: C₇H₁₃NO
• Molecular Weight: 127.1842
• Mol File: 4558-87-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 192.8°C at 760 mmHg
• Flash Point: 80.5°C
• Density: 0.915g/cm³
• Vapor Pressure: 0.48mmHg at 25°C
• Refractive Index: 1.43
• CAS DataBase Reference: 2,5-dimethylpiperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dimethylpiperidin-4-one(4558-87-6)
• EPA Substance Registry System: 2,5-dimethylpiperidin-4-one(4558-87-6)

Safety Data

• Hazardous Substances Data: 4558-87-6(Hazardous Substances Data)

Usage

Description

2,5-dimethylpiperidin-4-one is a colorless liquid chemical compound with the molecular formula C7H13NO. It belongs to the piperidine class of organic compounds and is characterized by its amine-like odor. This versatile intermediate is widely used in the synthesis of pharmaceuticals and agrochemicals.

Uses

Used in Pharmaceutical Industry:
2,5-dimethylpiperidin-4-one is used as a key building block for the synthesis of various drugs. Its unique structure allows for the development of new medicinal compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2,5-dimethylpiperidin-4-one serves as an essential intermediate in the production of agricultural chemicals. It contributes to the creation of innovative products designed to enhance crop protection and improve overall agricultural yields.
Used as a Chemical Intermediate:
2,5-dimethylpiperidin-4-one is utilized as an important intermediate in the synthesis of a wide range of compounds across various industries. Its versatility and reactivity make it a valuable component in the development of new chemical products.

Upstream product

• 220094-93-9 (1-methyl-2-ethoxycarbonylethyl)-(2-methyl-2-methoxycarbonylethyl)amine 
• 93583-33-6 trans-1-α-Phenylethyl-2R,5S-dimethyl-4-piperidone 
• 93583-33-6 1-α-Phenylethyl-2S,5ξ-dimethyl-4-piperidone 
• 1252678-28-6 ethyl 3-{[3-ethoxy-2-methyl-3-oxopropyl]amino}butanoate 
• 13058-39-4 (E)-2-methylhexa-1,4-dien-3-one 
• 41854-15-3 1,5-dimethoxy-2-methyl-hexan-3-one 

Downstream Products

• 39167-89-0 4-(3-buten-1-ynyl)-2,5-dimethylpiperidin-1-ol 
• 101496-66-6 2,5-dimethyl-1-(4-nitro-phenethyl)-piperidin-4-one 
• 109938-17-2 (2,5-dimethyl-4-oxo-piperidino)-phenyl-acetic acid methyl ester 
• 58476-13-4 2,5-dimethyl-4-oxo-piperidine-1-carboxylic acid ethyl ester 
• 101599-55-7 2,5-dimethyl-1-(3,4,5-trimethoxy-benzoyl)-piperidin-4-one 
• 63791-75-3 1-benzyl-2,5-dimethyl-piperidin-4-one 
• 107521-94-8 1-benzoyl-2,5-dimethyl-piperidin-4-one 
• 101939-13-3 2,5-dimethyl-1-(4-nitro-benzoyl)-piperidin-4-one 
• 102005-13-0 (+/-)-1-acetyl-2c,5c-dimethyl-4-phenyl-piperidin-4r-ol 
• 29280-78-2 1-(2-phenylethyl)-2,5-dimethyl-4-piperidone 
• 101105-60-6 2,5-dimethyl-4-oxo-piperidine-1-carboxylic acid benzyl ester 
• 102075-52-5 1-cinnamyl-2,5-dimethyl-piperidin-4-one 
• 100610-12-6 1-benzenesulfonyl-2,5-dimethyl-piperidin-4-one 
• 101738-79-8 2,5-dimethyl-1-(3-methyl-but-2-enyl)-piperidin-4-one 

Relevant articles and documents

Commercial synthesis of 2,5-dimethylpiperid-4-one

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ASYMMETRIC SYNTHESIS AND ABSOLUTE CONFIGURATION OF 1-α-PHENYLETHYL-2,5-DIMETHYL-4-PIPERIDONE ISOMERS

Reaction of the methyl iodide of trans-1,2-5-trimethyl-4-piperidone with S-α-phenylethylamine proceeds asymmetrically and leads in 66percent optical yield to the formation of the cis- and trans-diastereomeric pair of 1-(α-phenylethyl)-2,5-dimethyl-4-piperidone, in which the new asymmetric centers possess the 2S,5S- and 2S,5R-configurations, respectively.According to x-ray structural analysis, the minor trans-1-(α-phenylethyl)-2,5-dimethyl-4-piperidone component possesses the 2R,5S-configuration.The occurrence of asymmetric synthesis accompanying transamination was confirmed via the preparation of enantiomers of trans-2,5- and trans-1,2,5-trimethyl-4-piperidones.