456527-46-1

Basic information

• Product Name: tert-butyl (S)-(3-amino-4 -(benzylamino)-4-oxobutyl)carbamate
• Synonyms: tert-butyl (S)-(3-amino-4 -(benzylamino)-4-oxobutyl)carbamate
• CAS NO: 456527-46-1
• Molecular Formula: C₁₆H₂₅N₃O₃
• Molecular Weight: 307.388
• Mol File: 456527-46-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl (S)-(3-amino-4 -(benzylamino)-4-oxobutyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (S)-(3-amino-4 -(benzylamino)-4-oxobutyl)carbamate(456527-46-1)
• EPA Substance Registry System: tert-butyl (S)-(3-amino-4 -(benzylamino)-4-oxobutyl)carbamate(456527-46-1)

Safety Data

• Hazardous Substances Data: 456527-46-1(Hazardous Substances Data)

Usage

General Description

"Tert-butyl (S)-(3-amino-4-(benzylamino)-4-oxobutyl)carbamate" is a chemical compound with the molecular formula C16H25N3O3. It is a carbamate derivative and has a tert-butyl group attached to the nitrogen atom. The compound contains an amino group, a benzylamino group, and a carbonyl group, making it potentially useful in medicinal chemistry and drug development. It may have applications in the synthesis of pharmaceuticals and as a building block for more complex organic molecules due to its unique structural features. Further research and exploration are needed to fully understand the potential uses and properties of this chemical.

Upstream product

• 100-46-9 benzylamine 
• 125238-99-5 (S)-4-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid 
• 316152-95-1 (9H-fluoren-9-yl)methyl tert-butyl (4-(benzylamino)-4-oxobutane-1,3-diyl)(S)-dicarbamate 

Downstream Products

• 849948-79-4 (S)-4-methylnaphthalene-1-sulfonic acid [3-(N-Boc-amino)-1-benzylcarbamoylpropyl]amide 
• 315203-40-8 tert-butyl ((S)-3-((S)-2-amino-3-(3,4-difluorophenyl)propanamido)-4-(benzylamino)-4-oxobutyl)carbamate 

Relevant articles and documents

Characterization of Protease-Activated Receptor (PAR) ligands: Parmodulins are reversible allosteric inhibitors of PAR1-driven calcium mobilization in endothelial cells

Several classes of ligands for Protease-Activated Receptors (PARs) have shown impressive anti-inflammatory and cytoprotective activities, including PAR2 antagonists and the PAR1-targeting parmodulins. In order to support medicinal chemistry studies with hundreds of compounds and to perform detailed mode-of-action studies, it became important to develop a reliable PAR assay that is operational with endothelial cells, which mediate the cytoprotective effects of interest. We report a detailed protocol for an intracellular calcium mobilization assay with adherent endothelial cells in multiwell plates that was used to study a number of known and new PAR1 and PAR2 ligands, including an alkynylated version of the PAR1 antagonist RWJ-58259 that is suitable for the preparation of tagged or conjugate compounds. Using the cell line EA.hy926, it was necessary to perform media exchanges with automated liquid handling equipment in order to obtain optimal and reproducible antagonist concentration-response curves. The assay is also suitable for study of PAR2 ligands; a peptide antagonist reported by Fairlie was synthesized and found to inhibit PAR2 in a manner consistent with reports using epithelial cells. The assay was used to confirm that vorapaxar acts as an irreversible antagonist of PAR1 in endothelium, and parmodulin 2 (ML161) and the related parmodulin RR-90 were found to inhibit PAR1 reversibly, in a manner consistent with negative allosteric modulation.

SOMATOSTATIN RECEPTOR 1 AND/OR 4 SELECTIVE AGONISTS AND ANTAGONISTS

The invention relates to (hetero)arylsulfonylamino based peptidomimetics of formula (I), wherein R1, R2, R3, A, B, D, Q, k and n are defined as disclosed, or a pharmaceutically acceptable salt or ester thereof. Compounds of formula (I) possess high affinity and selectivity for the somatostatin receptor subtypes SSTR1 and/or SSTR4 and can be used for the treatment or diagnosis of diseases or conditions wherein an interaction with SSTR1 and/or SSTR4 is indicated to be useful.