45682-36-8

Basic information

• Product Name: (R)-1-(4-Pyridinyl)ethylaMine 2HCl
• Synonyms: (R)-1-(4-Pyridinyl)ethylaMine 2HCl;(R)-1-(4-Pyridyl)ethylaMine;(aR)-a-Methyl-4-PyridineMethanaMine;(R)-1-(4-Pyridyl)ethylaMine 2HCl;(R)-1-(pyridin-4-yl)ethanamine
• CAS NO: 45682-36-8
• Molecular Formula: C₇H₁₀N₂
• Molecular Weight: 195.08958
• Mol File: 45682-36-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 221.1±15.0 °C(Predicted)
• Appearance: /
• Density: 1.018±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.28±0.29(Predicted)
• CAS DataBase Reference: (R)-1-(4-Pyridinyl)ethylaMine 2HCl(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(4-Pyridinyl)ethylaMine 2HCl(45682-36-8)
• EPA Substance Registry System: (R)-1-(4-Pyridinyl)ethylaMine 2HCl(45682-36-8)

Safety Data

• Hazardous Substances Data: 45682-36-8(Hazardous Substances Data)

Usage

General Description

(R)-1-(4-Pyridinyl)ethylaMine 2HCl is a chemical compound that consists of a pyridine ring attached to an ethylamine group, with two hydrogen chloride molecules bound to the ethylamine group. It is often used as a reagent in chemical synthesis and as a precursor to other organic compounds. (R)-1-(4-Pyridinyl)ethylaMine 2HCl has potential applications in pharmaceuticals, agrochemicals, and material science. It is important to handle and store this chemical with care, as it can be hazardous if not used properly. Additionally, it is important to follow proper safety precautions when working with this compound, as exposure to it can cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 1122-54-9 methyl (4-pyridyl) ketone 
• 87227-77-8 bishydrochloride salt of cis-1,4-diamino-but-2-ene 
• 603999-02-6 4-[(1R)-1-azidoethyl]pyridine 
• 926921-88-2 (R_S)-N-[1-(pyridin-4-yl)ethylidene]-2-methylpropane-2-sulfinamide 
• 926921-92-8 (R_S,R)-N-[1-(pyridin-4-yl)ethyl]-2-methylpropane-2-sulfinamide 

Relevant articles and documents

But-2-ene-1,4-diamine and But-2-ene-1,4-diol as Donors for Thermodynamically Favored Transaminase- and Alcohol Dehydrogenase-Catalyzed Processes

Both cis- and trans-but-2-ene-1,4-diamines have been prepared and efficiently applied as sacrificial cosubstrates in enzymatic transamination reactions. The best results were obtained with the cis-diamine. The thermodynamic equilibrium of the stereoselective transamination process is shifted to the amine formation due to tautomerization of 5H-pyrrole into 1H-pyrrole, achieving high conversions (78–99%) and enantiomeric excess (up to >99%) by using a small excess of the amine donor. Furthermore, when the reaction proceeded, a strong coloration was observed due to polymerization of 1H-pyrrole. A structurally related compound, cis-but-2-ene-1,4-diol, has been utilized as cosubstrate in different alcohol dehydrogenase (ADH)-mediated bioreductions. In this case, high conversions (91–99%) were observed due to a lactonization process. Both strategies are convenient from both synthetic and atom economy points of view in the production of valuable optically active products. (Figure presented.).

Transaminases applied to the synthesis of high added-value enantiopure amines

Critical parameters affecting the stereoselective amination of (hetero)aromatic ketones using transaminases have been studied, such as temperature, pH, substrate concentration, cosolvent, and source and percentage of amino donor, to further optimize the production of enantiopure amines using both (S)- and (R)-selective biocatalysts from commercial suppliers. Interesting enantiopure amino building blocks have been obtained, overcoming some limitations of traditional chemical synthetic methods. Representative processes were scaled up, affording halogenated and heteroaromatic amines in enantiomerically pure form and good isolated yields.

A fast and sensitive assay for measuring the activity and enantioselectivity of transaminases

A fast and sensitive method for screening transaminase activity and enantioselectivity, using d- and l-amino acid oxidases, allows new amine substrates to be rapidly identified. The Royal Society of Chemistry 2011.